Bisphosphonates: new therapeutic agents for the treatment of bone tumors

Trends in Molecular Medicine
Dominique HeymannFrançoise Rédini

Abstract

Bisphosphonates (BPs) have been used successfully for many years to reduce the skeletal complications associated with the benign and malignant bone diseases that are characterized by enhanced osteoclastic bone resorption. Until recently, it was thought that the clinical efficacy of BPs in the treatment of cancer patients with bone metastases was purely a result of the inhibition of osteoclast-mediated bone resorption. However, recent studies have demonstrated that BPs inhibit the growth, attachment and invasion of cancer cells in culture and promote their apoptosis. These results suggest that BPs are also anti-cancer agents, raising the possibility that BPs could inhibit cancer-cell colonization in visceral organs. However, results from clinical trials are conflicting, and whether BPs possess anti-cancer effects or not remains controversial.

References

Mar 30, 1973·Calcified Tissue Research·A JungH Fleisch
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·J B Gibbs, A Oliff
Jul 3, 1998·International Journal of Cancer. Journal International Du Cancer·A SasakiT Matsumura
Aug 6, 1998·The New England Journal of Medicine·I J DielG Bastert
Feb 24, 2001·Critical Reviews in Eukaryotic Gene Expression·J M Chirgwin, T A Guise
Aug 24, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D R ClohisyM L Ramnaraine
Feb 22, 2002·Biochemical and Biophysical Research Communications·Volker ViereckLorenz C Hofbauer
Aug 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Trevor PowlesLiisa Pylkkänen
Oct 2, 2002·Breast Cancer Research and Treatment·Toshimi MichigamiToshiyuki Yoneda
Nov 1, 2002·Current Opinion in Oncology·Jonathan R Green
Mar 7, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Peter I CroucherKarin Vanderkerken
Feb 3, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Beiqing PanAndrew C W Zannettino
Feb 13, 2004·Health Technology Assessment : HTA·J R RossK Broadley

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Citations

Mar 20, 2009·Der Orthopäde·G Holzer
Apr 26, 2008·Apoptosis : an International Journal on Programmed Cell Death·Lilian SewingRüdiger Göke
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Carole BarbeyNathalie Dupont
Jul 21, 2007·Acta Pharmacologica Sinica·Te-jen LaiYi-chin Fong
Mar 27, 2012·Sarcoma·Kosei AndoDominique Heymann
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Angela HirbeKatherine Weilbaecher
Oct 19, 2011·Journal of Translational Medicine·Thea L Rogers, Ingunn Holen
Nov 1, 2007·Journal of Periodontology·Thomas A StatzGeorgia K Johnson
Apr 23, 2013·Clinical & Developmental Immunology·Taku FujimuraSetsuya Aiba
May 4, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Vassilios VassiliouDimitrios Kardamakis
Feb 10, 2007·Expert Review of Anticancer Therapy·François LamoureuxFrançoise Redini
Feb 10, 2007·Expert Review of Anticancer Therapy·M Baud'huinM Padrines
Sep 10, 2014·Journal of Drug Targeting·Tejinder SinghRavindra K Rawal
Apr 7, 2010·Expert Opinion on Drug Delivery·Dmitri A Ossipov
Aug 21, 2013·Expert Opinion on Emerging Drugs·Francoise RediniDominique Heymann
Jan 19, 2016·Frontiers in Oncology·Françoise Redini, Dominique Heymann
Dec 7, 2007·Bioorganic & Medicinal Chemistry Letters·Rotem ErezDoron Shabat
Mar 30, 2006·International Journal of Cancer. Journal International Du Cancer·François GouinDominique Heymann
Jul 10, 2008·Rapid Communications in Mass Spectrometry : RCM·Julie HardouinMarc Lecouvey
Oct 26, 2007·International Journal of Cancer. Journal International Du Cancer·François LamoureuxFrançoise Redini
Apr 7, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Z Y LiK D K Luk
Jan 24, 2008·Pediatric Blood & Cancer·Anita MahajanPete Anderson
May 23, 2008·Journal of Cellular and Molecular Medicine·B OryD Heymann
Jun 30, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Séverine BattagliaFrançoise Redini
Jan 7, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Stéphane TéletchéaDominique Heymann
Aug 1, 2015·Biomacromolecules·Laura ColomboBarbara La Ferla
Apr 12, 2015·International Journal of Oral and Maxillofacial Surgery·T ShintaniT Okamoto

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