Bisphosphonates: ready for use as adjuvant therapy of breast cancer?

Current Opinion in Obstetrics & Gynecology
Richard L Theriault

Abstract

To describe recent data on the effects of bisphosphonates on bone health for patients with primary breast cancer. Data are accumulating regarding the salutary effect of bisphosphonates on bone health. Preservation of bone mineral density, a surrogate for fracture risk, has been demonstrated in randomized controlled trials of bisphosphonates. These trials have included premenopausal and postmenopausal women and endocrine and chemotherapy adjuvant breast cancer treatments. In these trials there has been a focus on gonadal dysfunction, use of aromatase inhibitors and the risk of osteopenia/osteoporosis. Data with bisphosphonates in this clinical setting have not confirmed clinical benefit for fracture risk.Adjuvant studies to assess the prevention of bone metastases have appropriate scientific rationale, including the potential antitumor effects of bisphosphonates, but large randomized controlled trials are incomplete. The use of a bisphosphonate is warranted for preservation of bone mineral density in women with primary breast cancer and gonadal dysfunction or drug-induced hypoestrogenism. The potential additional benefit of delay or prevention of bone metastasis awaits confirmation from randomized controlled trials.Expert consen...Continue Reading

References

Mar 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P D DelmasA Bremond
May 20, 1998·Journal of the National Cancer Institute·T J PowlesJ Kanis
Jun 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G N HortobagyiD J Reitsma
Mar 10, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R L TheriaultD J Reitsma
Nov 27, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L VehmanenC Blomqvist
Aug 30, 2003·BMJ : British Medical Journal·J R RossS R D Johnston
Sep 10, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce E HillnerUNKNOWN American Society of Clinical Oncology
Apr 16, 2004·The New England Journal of Medicine·G David Roodman
Aug 31, 2004·Palliative Medicine·Y SaundersUNKNOWN Steering Group
Apr 13, 2005·Clinical Therapeutics·Debu TripathyBengt Bergström
Feb 14, 2006·The Breast : Official Journal of the European Society of Mastology·Umberto VeronesiAron Goldhirsch
Jun 8, 2006·Nature Clinical Practice. Oncology·Daniele SantiniGiuseppe Tonini
Dec 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Adam BrufskyEdith A Perez
Dec 14, 2006·Clinical Drug Investigation·Martin PecherstorferBengt Bergström
Jan 4, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alan S CoatesAron Goldhirsch
Aug 11, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J J BodyJ M Kaufman
Aug 19, 2007·Current Medicinal Chemistry·Takeshi YuasaTaira Maekawa
Oct 2, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M AaproB Thürlimann
Dec 7, 2007·Cancer Biology & Therapy·Mojtaba AkhtariPrem Seth
Mar 4, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard EastellGlen Clack
Mar 12, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J N IngleP E Goss
Apr 22, 2008·Cancer Treatment Reviews·M C WinterR E Coleman
Apr 23, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan L GreenspanVictor G Vogel
May 2, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P HadjiM Tubiana-Hulin
Jul 31, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·I J DielF Schuetz
Aug 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dawn L HershmanElizabeth Shane
Sep 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tiina SaartoInkeri Elomaa
Oct 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·James E LesterRobert E Coleman
Oct 29, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fred SaadKathleen I Pritchard
Dec 17, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephanie L HinesEdith A Perez
Feb 14, 2009·The New England Journal of Medicine·Michael GnantC Marth
May 29, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M RabaglioUNKNOWN BIG 1-98 Collaborative and International Breast Cancer Study Groups

❮ Previous
Next ❯

Citations

Sep 11, 2012·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Adeel R MemonJames A Harty

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
Bhoomi Mehrotra
© 2022 Meta ULC. All rights reserved