PMID: 26827062Feb 2, 2016Paper

Bisphosphonates, vitamin D, parathyroid hormone, and osteonecrosis of the jaw. Could there be a missing link?

Medicina oral, patología oral y cirugía bucal
Ignacio-Osoitz Leizaola-CardesaGerardo Gómez-Moreno

Abstract

It is estimated that over 190 million bisphosphonates have been prescribed worldwide. But this drug can produce adverse effects, of which osteonecrosis of the jaw and severe hypocalcemia are the most serious. It is evident that bisphosphonate administration affects multiple and diverse biochemical mediators related to bone metabolism. This review of literature investigates four basic parameters in patients treated with bisphosphonates - parathyroid hormone (PTH), bisphosphonates, vitamin D, calcium, and jaw osteonecrosis - which are fundamental for assessing bone metabolism and so the efficacy and correct use of the drug. The imbalances generated by vitamin D and calcium deficiencies, together with their multiple systemic repercussions, have been widely researched but the outcomes of these imbalances in relation to bisphosphonate administration are not well known, and some research has indicated that they may be associated with osteonecrosis of the jaw (ONJ). The present review set out to explain the functioning of bone metabolism, the importance of different chemical mediators, the imbalances produced by incorrect use of this drug, in order to forewarn against the possible relation of these parameters with ONJ, whose physiopat...Continue Reading

Citations

Mar 11, 2017·Journal of Biomedical Materials Research. Part a·Angel InsuaRichard J Miron
Jul 13, 2018·Applied Microbiology and Biotechnology·Valery M DembitskyNick Savidov
Apr 12, 2016·Oral Diseases·P CeponisJ J Freiberger
Aug 5, 2021·Tissue Engineering and Regenerative Medicine·Gwanghyun YangBu-Kyu Lee

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