Bitter-responsive gustatory neurons in the rat parabrachial nucleus.

Journal of Neurophysiology
Laura C Geran, Susan P Travers

Abstract

Bitterness is a distinctive taste sensation, but central coding for this quality remains enigmatic. Although some receptor cells and peripheral fibers are selectively responsive to bitter ligands, central bitter responses are most typical in broadly tuned neurons. Recently we reported more specifically tuned bitter-best cells (B-best) in the nucleus of the solitary tract (NST). Most had glossopharyngeal receptive fields and few projected to the parabrachial nucleus (PBN), suggesting a role in reflexes. To determine their potential contribution to other functions, the present study investigated whether B-best neurons occur further centrally. Responses from 90 PBN neurons were recorded from anesthetized rats. Stimulation with four bitter tastants (quinine, denatonium, propylthiouracil, cycloheximide) and sweet, umami, salty, and sour ligands revealed a substantial proportion of B-best cells (22%). Receptive fields for B-best NST neurons were overwhelmingly foliate in origin, but in PBN, about half received foliate and nasoincisor duct input. Despite convergence, most B-best PBN neurons were as selectively tuned as their medullary counterparts and response profiles were reliable. Regardless of intensity, cycloheximide did not acti...Continue Reading

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Citations

Oct 4, 2011·Frontiers of Medicine·Ke ChenXiaolin Zhao
May 25, 2011·Behavioral Neuroscience·Laura C Geran, Susan P Travers
Jan 27, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Takeshi SuzukiBill J Yates
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Oct 10, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Laura E MartinAnn-Marie Torregrossa
Apr 29, 2018·Trends in Neurosciences·Richard D Palmiter
Apr 29, 2021·Journal of Neurophysiology·Louis J MartinSuzanne I Sollars

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