Bitter taste receptor T2R1 activities were compatible with behavioral sensitivity to bitterness in chickens

Biochemical and Biophysical Research Communications
Nozomi HiroseShoji Tabata

Abstract

Clarification of the mechanism of the sense of taste in chickens will provide information useful for creating and improving new feedstuffs for chickens, because the character of the taste receptors in oral tissues affects feeding behavior in animals. In this study, we focused on the sensitivity to bitterness in chickens. We cloned one of the bitter taste receptors, T2R1, from the chicken palate, constructed several biosensor-cells expressing chicken T2R1 (cT2R1), and determined a highly sensitive biosensor of cT2R1 among them. By using Ca(2+) imaging methods, we identified two agonists of cT2R1, dextromethorphan (Dex) and diphenidol (Dip). Dex was a new agonist of cT2R1 that was more potent than Dip. In a behavioral drinking study, the intake volumes of solutions of these compounds were significantly lower than that of water in chickens. These aversive concentrations were identical to the concentrations that could activate cT2R1 in a cell-based assay. These results suggest that the cT2R1 activities induced by these agonists are linked to behavioral sensitivity to bitterness in chickens.

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Citations

Sep 12, 2015·Biochemical and Biophysical Research Communications·Yuta YoshidaShoji Tabata
Sep 19, 2016·Biochemical and Biophysical Research Communications·Nandakumar VenkatesanHong-Xiang Liu
May 18, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shira Cheled-ShovalMasha Y Niv
Feb 16, 2018·Frontiers in Molecular Biosciences·Antonella Di PizioMasha Y Niv
Jun 12, 2018·Nutrition Research Reviews·Shahram Niknafs, Eugeni Roura
Nov 18, 2016·Scientific Reports·Prasangi RajapakshaHong-Xiang Liu
Jan 1, 2018·The Journal of Poultry Science·Tatsuyuki YoshidaHiroki Furuta
Aug 1, 2020·The Journal of Poultry Science·Fuminori KawabataShoji Tabata
Feb 21, 2019·Biochemical and Biophysical Research Communications·Yuta YoshidaFuminori Kawabata
May 12, 2021·Poultry Science·Yuta YoshidaHong-Xiang Liu

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