Bitter Taste Receptors for Asthma Therapeutics

Frontiers in Physiology
Ajay P NayakDeepak A Deshpande

Abstract

Clinical management of asthma and chronic obstructive pulmonary disease (COPD) has primarily relied on the use of beta 2 adrenergic receptor agonists (bronchodilators) and corticosteroids, and more recently, monoclonal antibody therapies (biologics) targeting specific cytokines and their functions. Although these approaches provide relief from exacerbations, questions remain on their long-term efficacy and safety. Furthermore, current therapeutics do not address progressive airway remodeling (AR), a key pathological feature of severe obstructive lung disease. Strikingly, agonists of the bitter taste receptors (TAS2Rs) deliver robust bronchodilation, curtail allergen-induced inflammatory responses in the airways and regulate airway smooth muscle (ASM) cell proliferation and mitigate features of AR in vitro and in animal models. The scope of this review is to provide a comprehensive and systematic insight into our current understanding of TAS2Rs with an emphasis on the molecular events that ensue TAS2R activation in distinct airway cell types and expand on the pleiotropic effects of TAS2R targeting in mitigating various pathological features of obstructive lung diseases. Finally, we will discuss specific opportunities that could ...Continue Reading

References

Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S C KinnamonK G Beam
Oct 23, 1998·Nature·S UgawaS Shimada
Aug 19, 1999·The Journal of Allergy and Clinical Immunology·R BeasleyC Burgess
Apr 13, 2000·Cell·E AdlerC S Zuker
Apr 13, 2000·Cell·J ChandrashekarN J Ryba
Sep 12, 2000·Current Opinion in Neurobiology·T A GilbertsonR F Margolskee
May 2, 2001·Journal of Neurochemistry·E SainzS L Sullivan
Nov 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·S PageC L Armour
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·S Vincent WuEnrique Rozengurt
May 31, 2002·The New England Journal of Medicine·Christopher E BrightlingIan D Pavord
Aug 27, 2002·Emerging Infectious Diseases·Rodney M Donlan
Jul 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Thomas E FingerWayne L Silver
Nov 8, 2003·Cells, Tissues, Organs·A Sbarbati, F Osculati
Jun 5, 2004·Biochemical and Biophysical Research Communications·Maik BehrensWolfgang Meyerhof
Aug 30, 2005·Annual Review of Genomics and Human Genetics·Dennis Drayna
Nov 16, 2005·Pulmonary Pharmacology & Therapeutics·John V Bonacci, Alastair G Stewart
Dec 13, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Motoko YasutomiMitsufumi Mayumi
May 30, 2006·Cellular and Molecular Life Sciences : CMLS·M Behrens, W Meyerhof
Jul 11, 2006·Cellular Signalling·Deepak A Deshpande, Raymond B Penn
Sep 2, 2006·Annual Review of Physiology·Matthias Salathe
Oct 7, 2006·Cell and Tissue Research·Flavia MerigoAndrea Sbarbati
Apr 21, 2007·Annual Review of Nutrition·Alexander A Bachmanov, Gary K Beauchamp
May 15, 2007·Prostaglandins & Other Lipid Mediators·Caroline MorinEric Rousseau
Jan 11, 2008·Current Opinion in Endocrinology, Diabetes, and Obesity·Catia SterniniEnrique Rozengurt
Apr 18, 2008·Journal of Neurophysiology·Brian D GulbransenSue C Kinnamon
Sep 27, 2008·Neuron·Bernd Fakler, John P Adelman
Jun 26, 2009·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Hiromi OginoJunko Kizu
Jul 25, 2009·Science·Alok S ShahMichael J Welsh
Dec 9, 2009·The Journal of Allergy and Clinical Immunology·Margaret M KellyPaul M O'Byrne
Dec 22, 2009·Chemical Senses·Wolfgang MeyerhofMaik Behrens
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Marco TizzanoThomas E Finger
Feb 24, 2010·The American Journal of Medicine·Shelley R SalpeterNicholas S Buckley
Apr 14, 2010·Molecular Medicine·Hanna SchierbeckHelena Erlandsson Harris
May 11, 2010·The Journal of Allergy and Clinical Immunology·Muhannad HassanJames G Martin
Jul 2, 2010·Current Opinion in Pharmacology·Rabih HalwaniQutayba Hamid
Aug 11, 2010·The Journal of Cell Biology·Nirupa Chaudhari, Stephen D Roper
Sep 2, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Huandong YanRaymond B Penn
Dec 24, 2010·British Journal of Pharmacology·J K L WalkerR A Bond
Jan 15, 2011·BMC Pulmonary Medicine·Marco TizzanoThomas E Finger

❮ Previous
Next ❯

Citations

Feb 8, 2020·The Annals of Otology, Rhinology, and Laryngology·David T LiuBertold Renner
May 15, 2020·Biological & Pharmaceutical Bulletin·Mingzhi LuoLinhong Deng
Jul 28, 2020·International Journal of Molecular Sciences·Joanna Jeruzal-ŚwiąteckaWioletta Pietruszewska
Jul 4, 2020·The European Respiratory Journal·Raymond B Penn
Oct 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maik Behrens, Florian Ziegler
Jun 9, 2020·Frontiers in Medicine·Kenneth P HoughVictor J Thannickal
Feb 2, 2021·American Journal of Respiratory Cell and Molecular Biology·Aabida SaferaliCraig P Hersh
May 7, 2020·Current Opinion in Pharmacology·Brijeshkumar S PatelY S Prakash
Jun 27, 2021·The Journal of Membrane Biology·Mercedes Alfonso-Prieto
Jul 27, 2021·Frontiers in Nutrition·Gabriella MoriniAngela Bassoli
Aug 28, 2021·International Journal of Molecular Sciences·Sachiko KoyamaThomas Heinbockel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.