Bivariate association analyses for the mixture of continuous and binary traits with the use of extended generalized estimating equations

Genetic Epidemiology
Jian-Feng LiuHong-Wen Deng

Abstract

Genome-wide association (GWA) study is becoming a powerful tool in deciphering genetic basis of complex human diseases/traits. Currently, the univariate analysis is the most commonly used method to identify genes associated with a certain disease/phenotype under study. A major limitation with the univariate analysis is that it may not make use of the information of multiple correlated phenotypes, which are usually measured and collected in practical studies. The multivariate analysis has proven to be a powerful approach in linkage studies of complex diseases/traits, but it has received little attention in GWA. In this study, we aim to develop a bivariate analytical method for GWA study, which can be used for a complex situation in which continuous trait and a binary trait are measured under study. Based on the modified extended generalized estimating equation (EGEE) method we proposed herein, we assessed the performance of our bivariate analyses through extensive simulations as well as real data analyses. In the study, to develop an EGEE approach for bivariate genetic analyses, we combined two different generalized linear models corresponding to phenotypic variables using a seemingly unrelated regression model. The simulation r...Continue Reading

References

Oct 1, 1992·Statistics in Medicine·S L Zeger, K Y Liang
Jul 1, 1996·Archives of Disease in Childhood. Fetal and Neonatal Edition·L MooreG Falconer
Sep 13, 1996·Science·N Risch, K Merikangas
Oct 3, 1998·American Journal of Human Genetics·D B AllisonN J Schork
May 29, 2000·American Journal of Human Genetics·J K PritchardP Donnelly
Aug 19, 2000·Risk Analysis : an Official Publication of the Society for Risk Analysis·M M Regan, P J Catalano
Apr 21, 2001·European Journal of Human Genetics : EJHG·J AkeyM Xiong
Jan 23, 2002·Molecular Psychiatry·N Weidner, M H Tuszynski
Mar 23, 2002·The Pharmacogenomics Journal·S T WeissLyle J Palmer
Mar 25, 2005·Genetic Epidemiology·Claudio J VerzilliJohn C Whittaker
Oct 12, 2005·Statistics in Medicine·R V Gueorguieva, G Sanacora
Feb 15, 2007·The Journal of Clinical Endocrinology and Metabolism·Lanjuan ZhaoHong-Wen Deng
Aug 2, 2007·American Journal of Human Genetics·Jian-Feng LiuHong-Wen Deng
Sep 6, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lanjuan ZhaoHong-Wen Deng
Oct 10, 2007·American Journal of Human Genetics·Wei-Min Chen, Goncalo R Abecasis

Citations

Aug 29, 2012·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Osamu NemotoYou Ukegawa
Jun 6, 2009·Annals of Human Genetics·Yufang PeiHong-Wen Deng
Jun 8, 2011·Annals of the Rheumatic Diseases·Gregory LivshitsFrances M K Williams
May 1, 2012·Journal of Probability and Statistics·Qiong Yang, Yuanjia Wang
Mar 1, 2012·BMC Proceedings·Mengdie Yuan, Guoqing Diao
Apr 26, 2014·PloS One·Tessel E GaleslootSita H Vermeulen
Aug 31, 2013·Briefings in Bioinformatics·R YangYongxin Liu
Feb 16, 2016·Nature Reviews. Genetics·William S BushDana C Crawford
Jul 22, 2014·Genetic Epidemiology·Qunyuan ZhangIngrid B Borecki
Dec 14, 2011·Genetic Epidemiology·Phillip E Melton, Nathan Pankratz
May 3, 2012·Animal Genetics·J Y WangQ Zhang
Jun 21, 2012·Genetic Epidemiology·Janina S RiedChristian Gieger
Aug 18, 2012·Genetic Epidemiology·Arnab MaityJun-Ying Tzeng
Jan 28, 2014·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·David C GlahnLaura Almasy
Apr 7, 2010·Preventive Veterinary Medicine·J B OsterstockN D Cohen
Jul 22, 2015·PloS One·Binod Neupane, Joseph Beyene
Dec 22, 2017·Biostatistics·Daniel J SchaidJoanna M Biernacka
Aug 21, 2014·Nature Communications·Jean MonlongRoderic Guigó
Jun 12, 2013·Nature Reviews. Genetics·Nadia SolovieffJordan W Smoller
Nov 3, 2017·Open Biology·Sophie Hackinger, Eleftheria Zeggini
Jan 20, 2016·Genetic Epidemiology·Baolin Wu, James S Pankow
Dec 3, 2016·Genetic Epidemiology·Sharon M LutzChristoph Lange
May 11, 2018·Computational and Mathematical Methods in Medicine·Baolin Wu, James S Pankow
Oct 27, 2016·European Journal of Human Genetics : EJHG·Shuai WangJosée Dupuis
Sep 19, 2019·Journal of the American Medical Informatics Association : JAMIA·Ruowang LiYong Chen
Jan 9, 2017·G3 : Genes - Genomes - Genetics·Riyan ChengJustin Borevitz
Aug 17, 2016·Genetics·Daniel J SchaidJason P Sinnwell
May 7, 2020·Statistical Applications in Genetics and Molecular Biology·Mariza de AndradeNubia E Duarte
Feb 27, 2021·Statistical Methods in Medical Research·Qihuang Zhang, Grace Y Yi

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.