Bivariate association analysis for quantitative traits using generalized estimation equation

Journal of Genetics and Genomics = Yi Chuan Xue Bao
Fang YangHongwen Deng

Abstract

Quantitative traits often underlie risk for complex diseases. Many studies collect multiple correlated quantitative phenotypes and perform univariate analyses on each of them respectively. However, this strategy may not be powerful and has limitations to detect pleiotropic genes that may underlie correlated quantitative traits. In addition, testing multiple traits individually will exacerbate perplexing problem of multiple testing. In this study, generalized estimating equation 2 (GEE2) is applied to association mapping of two correlated quantitative traits. We suppose that a quantitative trait locus is located in a chromosome region that exerts pleiotropic effects on multiple quantitative traits. In that region, multiple SNPs are genotyped. Genotypes of these SNPs and the two quantitative traits affected by a causal SNP were simulated under various parameter values: residual correlation coefficient between two traits, causal SNP heritability, minor allele frequency of the causal SNP, extent of linkage disequilibrium with the causal SNP, and the test sample size. By power analytical analyses, it is showed that the bivariate method is generally more powerful than the univariate method. This method is robust and yields false-posi...Continue Reading

References

Sep 1, 1989·Annals of Internal Medicine·S L HuiC C Johnston
Jan 1, 1993·Genetic Epidemiology·C I Amos, A E Laing
Mar 4, 2000·Clinical Cornerstone·L KhaodhiarG L Blackburn
Jun 3, 2000·Genetics·J K PritchardP Donnelly
Mar 20, 2001·American Journal of Human Genetics·M StephensP Donnelly
Feb 13, 2002·European Journal of Human Genetics : EJHG·P Hedrick, S Kumar
Mar 14, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Fei-Yan DengHong-Wen Deng
May 3, 2007·The Journal of Clinical Endocrinology and Metabolism·Zi-Hui TangHong-Wen Deng
Aug 4, 2007·Calcified Tissue International·D KarasikS Demissie
Jun 6, 2009·Annals of Human Genetics·Yu-Fang PeiHong-Wen Deng

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Citations

Apr 26, 2014·PloS One·Tessel E GaleslootSita H Vermeulen
Aug 31, 2013·Briefings in Bioinformatics·Runqing YangYongxin Liu
Dec 14, 2011·Genetic Epidemiology·Phillip E Melton, Nathan Pankratz
Jul 22, 2015·PloS One·Binod Neupane, Joseph Beyene

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