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Bivariate Genome-Wide Association Scan Identifies 6 Novel Loci Associated With Lipid Levels and Coronary Artery Disease

Circulation. Genomic and Precision Medicine

Dec 12, 2018

Katherine M Siewert, Benjamin F Voight

Abstract

Plasma lipid levels are heritable and genetically associated with risk of coronary artery disease (CAD). However, genome-wide association studies (GWAS) routinely analyze these traits independent of one another. Joint GWAS for two related phenotypes can lead to a higher powered analysis...read more

Mentioned in this Paper

Genome-Wide Association Study
Meta Analysis (Statistical Procedure)
Genome
Genes
Coronary Artery Disease
International Consortium on Prostate Cancer Genetics
Coronary Arteriosclerosis
Plasma
High Density Lipoprotein Cholesterol
Cholesteryl Linoleate, LDL
7
30
Paper Details
References
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  • Citations1
1234
  • References39
  • Citations1
1

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Bivariate Genome-Wide Association Scan Identifies 6 Novel Loci Associated With Lipid Levels and Coronary Artery Disease

Circulation. Genomic and Precision Medicine

Dec 12, 2018

Katherine M Siewert, Benjamin F Voight

PMID: 30525989

DOI: 10.1161/circgen.118.002239

Abstract

Plasma lipid levels are heritable and genetically associated with risk of coronary artery disease (CAD). However, genome-wide association studies (GWAS) routinely analyze these traits independent of one another. Joint GWAS for two related phenotypes can lead to a higher powered analysis...read more

Mentioned in this Paper

Genome-Wide Association Study
Meta Analysis (Statistical Procedure)
Genome
Genes
Coronary Artery Disease
International Consortium on Prostate Cancer Genetics
Coronary Arteriosclerosis
Plasma
High Density Lipoprotein Cholesterol
Cholesteryl Linoleate, LDL
7
30

Similar Papers Found In These Feeds

Gene Regulatory Networks (Keystone)

Gene regulatory networks are comprised of molecular regulators that interact with each other and other factors in a cell to regulate and modulate gene expression. Here is the latest research.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Related Papers

Circulation. Cardiovascular Genetics

Multiple associated variants increase the heritability explained for plasma lipids and coronary artery disease

Circulation. Cardiovascular GeneticsAugust 30, 2014
Hayato TadaSekar Kathiresan
Paper Details
References
  • References39
  • Citations1
1234
  • References39
  • Citations1
1
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