Bivariate phase-rectified signal averaging for assessment of spontaneous baroreflex sensitivity: pilot study of the technology

Journal of Electrocardiology
A BauerGeorg Schmidt

Abstract

Assessment of spontaneous baroreflex sensitivity (BRS), an index of autonomic function, poses practical challenges. In this pilot study, we propose a novel technique for assessment of spontaneous BRS based on bivariate phase-rectified signal averaging (PRSA). This is an extension of the monovariate PRSA technology used for calculation of deceleration capacity. A prospective, observational study was conducted in a training cohort of 146 patients with heart failure (New York Heart Association class 2.7 ± 0.8, left ventricular ejection fraction 23.6% ± 9.0%) presenting with sinus rhythm. In all patients, 10-minute recordings of ECG and arterial and blood pressure were obtained in the supine resting position. The algorithm for BRS assessment based on bivariate PRSA (BRS(PRSA)) included (1) identification of heartbeat intervals occurring at the time of systolic pressure increases, (2) selection of heartbeat adjacent interval sections, (3) alignment and (4) averaging of these segments, and (5) quantification of the average heart beat interval change by Haar wavelet analysis. Primary end point was death of any cause. During mean follow-up of 2.7 ± 1.1 years, 42 patients (28.8%) died. BRS(PRSA) was significantly associated with the pri...Continue Reading

References

Apr 23, 2008·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Maria Teresa La RovereGrzegorz Raczak
Jan 10, 2009·Journal of the American College of Cardiology·Maria Teresa La RovereOreste Febo
Mar 3, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Richard L VerrierBruce D Nearing

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Citations

Apr 21, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Petra BarthelGeorg Schmidt
Mar 1, 2011·Journal of Electrocardiology·Paolo CastiglioniGianfranco Parati
Jan 18, 2011·Journal of Cardiovascular Electrophysiology·Marek Malik
Feb 11, 2014·Journal of the American College of Cardiology·Christine S ZuernAxel Bauer
Aug 27, 2013·Journal of the American College of Cardiology·Christine S ZuernAxel Bauer
May 14, 2016·Journal of the American College of Cardiology·Daniel SinneckerGeorg Schmidt
Jun 5, 2014·Journal of the American Heart Association·Daniel SinneckerGeorg Schmidt
Nov 9, 2018·Medicine and Science in Sports and Exercise·Michael F LA FountaineJoseph P Weir
Aug 1, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Beatrice De MariaAlberto Porta
Jun 17, 2015·Journal of Cardiovascular Pharmacology·Yan-Ying Feng, Zhi-Jun Yang
Mar 24, 2015·Physiological Measurement·Gian Domenico PinnaMaria Teresa La Rovere
Jul 17, 2020·Frontiers in Physiology·Maria Teresa La RoverePeter J Schwartz
Jan 30, 2021·Frontiers in Physiology·Pablo VázquezNatàlia Balagué
Sep 5, 2021·Annals of the New York Academy of Sciences·Michael F La FountaineJoseph P Weir

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