Bivariate random-effects meta-analysis models for diagnostic test accuracy studies using arcsine-based transformations

Biometrical Journal. Biometrische Zeitschrift
Zelalem F NegeriJoseph Beyene

Abstract

Diagnostic or screening tests are widely used in medical fields to classify patients according to their disease status. Several statistical models for meta-analysis of diagnostic test accuracy studies have been developed to synthesize test sensitivity and specificity of a diagnostic test of interest. Because of the correlation between test sensitivity and specificity, modeling the two measures using a bivariate model is recommended. In this paper, we extend the current standard bivariate linear mixed model (LMM) by proposing two variance-stabilizing transformations: the arcsine square root and the Freeman-Tukey double arcsine transformation. We compared the performance of the proposed methods with the standard method through simulations using several performance measures. The simulation results showed that our proposed methods performed better than the standard LMM in terms of bias, root mean square error, and coverage probability in most of the scenarios, even when data were generated assuming the standard LMM. We also illustrated the methods using two real data sets.

References

Sep 25, 2001·Statistics in Medicine·C M Rutter, C A Gatsonis
Jun 18, 2005·Clinical Chemistry·Anne W S RutjesPatrick M M Bossuyt
Sep 20, 2005·Journal of Clinical Epidemiology·Johannes B ReitsmaAeilko H Zwinderman
May 16, 2006·Biostatistics·Roger M HarbordJonathan A C Sterne
Jun 27, 2007·Statistics in Medicine·Gerta RückerJames Carpenter
Dec 18, 2007·Journal of Clinical Epidemiology·Taye H HamzaTheo Stijnen
Jul 2, 2008·Medical Decision Making : an International Journal of the Society for Medical Decision Making·L R ArendsT Stijnen
Aug 30, 2008·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Taye H HamzaTheo Stijnen
Dec 5, 2009·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Haitao ChuYijie Zhou
May 16, 2012·Psychological Methods·Philipp DoeblerDankmar Böhning
Aug 22, 2013·Journal of Epidemiology and Community Health·Jan J BarendregtTheo Vos
Apr 25, 2014·BMC Medical Research Methodology·Suphada CharoensawatHeinz Holling
Jan 1, 2014·Archives of public health = Archives belges de santé publique·Victoria N NyagaMarc Aerts

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Citations

Jun 18, 2019·Statistical Methods in Medical Research·Zelalem F Negeri, Joseph Beyene
Oct 17, 2020·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Srilakshmi Mandayam AdhyapakTinku Thomas

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