Biventricular diastolic dysfunction, thrombocytopenia, and red blood cell macrocytosis in experimental pulmonary arterial hypertension.

Pulmonary Circulation
Ji Young LeeTroy Stevens

Abstract

Pulmonary arterial hypertension is a fatal disease, where death is associated with right heart failure and reduced cardiorespiratory reserve. The Sugen 5416, hypoxia and normoxia Fischer rat model mimics human pulmonary arterial hypertension, although the cause(s) of death remains incompletely understood. Here, we hypothesized that these animals develop biventricular diastolic dysfunction that contributes to tissue hypoperfusion coincident with severe pulmonary arterial hypertension. We performed comprehensive echocardiographic and hematologic assessments. Serial echocardiogram at 3-5 weeks was performed followed by blood sampling via aortic or cardiac puncture. Echocardiogram revealed pulmonary arterial hypertension in pulmonary artery Doppler waves, including notched wave envelopes, and decreased pulmonary artery acceleration time/pulmonary artery ejection time ratio and right ventricular outflow tract velocity time integral. Impaired right ventricular systolic function, assessed by decreased tricuspid annular plane systolic excursion and tricuspid tissue Doppler systolic positive wave velocity, was observed in pulmonary arterial hypertension. Tricuspid and mitral pulsed wave and tissue Doppler findings suggested biventricula...Continue Reading

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Citations

Jul 7, 2020·American Journal of Respiratory Cell and Molecular Biology·Ji Young LeeTroy Stevens
Aug 13, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ron BalczonTroy Stevens
Jul 13, 2021·American Journal of Respiratory Cell and Molecular Biology·Ji Young LeeTroy Stevens

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Methods Mentioned

BETA
coronary artery ligation

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