Biventricular pacing has an advantage over left ventricular epicardial pacing alone to minimize proarrhythmic perturbation of repolarization

Journal of Cardiovascular Electrophysiology
Masahide HaradaItsuo Kodama

Abstract

Cardiac resynchronization therapy (CRT) by simultaneous biventricular pacing is now widely accepted as a new therapeutic option for patients with severe congestive heart failure (CHF). Recent studies have shown comparable hemodynamic benefits of left ventricular (LV) pacing alone. The clinical usefulness of CRT, however, might be compromised by potential exaggeration of arrhythmogenic substrates through a modification of ventricular repolarization. We compared ECG parameters during sinus rhythm (SR), atrioventricular synchronous pacing at the right ventricular apex (RV(end)P), at LV epicardium (LV(epi)P), and at both sites (BiVP) in acute homodynamic studies of 14 CHF patients scheduled for CRT (QRS duration = 144 +/- 23 msec, LVEF = 27 +/- 10%). The maximum rate of increase in LV pressure (LVdp/dt(max)) was decreased significantly during RV(end)P, whereas it was increased similarly during LV(epi)P and BiVP compared with SR. QTc was increased during RV(end)P (by 10.2%) and LV(epi)P (by 26.1%). QTc dispersion (QTc(max)-QTc(min) in the six precordial leads) was also increased during LV(epi)P (by 66.5%). These parameters were unaffected during BiVP. JTc was unchanged, and the interval from the peak to the end of the T wave (Tc(pea...Continue Reading

References

Jan 1, 1978·Cardiovascular Research·D Noble, I Cohen
Nov 1, 1988·British Heart Journal·J C CowanR W Campbell
Jun 1, 1986·Journal of the American College of Cardiology·J A VassalloM E Josephson
Nov 1, 1982·The American Journal of Cardiology·K F BrowneE N Prystowsky
Jan 19, 2000·Nature·D di Bernardo, A Murray
Sep 15, 2000·Journal of the American College of Cardiology·S Saksena
Mar 20, 2001·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·M R Franz
Mar 22, 2001·The New England Journal of Medicine·S CazeauUNKNOWN Multisite Stimulation in Cardiomyopathies (MUSTIC) Study Investigators
May 30, 2001·Cardiovascular Research·C Antzelevitch
Jun 14, 2002·The New England Journal of Medicine·William T AbrahamUNKNOWN MIRACLE Study Group. Multicenter InSync Randomized Clinical Evaluation
May 14, 2003·Journal of Cardiovascular Electrophysiology·Imad Libbus, David S Rosenbaum
Dec 19, 2003·Journal of the American College of Cardiology·Angelo AuricchioUNKNOWN Guidant Heart Failure Research Group
May 20, 2004·Journal of Cardiovascular Electrophysiology·Gabe B BleekerJeroen J Bax
May 21, 2004·The New England Journal of Medicine·Michael R BristowUNKNOWN Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Robert C KowalMohamed H Hamdan
Jun 11, 2005·Journal of Cardiovascular Electrophysiology·Thomas BergerFranz X Roithinger
Jun 11, 2005·Journal of Cardiovascular Electrophysiology·Andrew MykytseyRichard Kehoe
Sep 30, 2005·Journal of Cardiovascular Electrophysiology·Bart Hooft Van HuysduynenMartin J Schalij

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Citations

Jan 25, 2012·Journal of Cardiovascular Translational Research·Takeshi Aiba, Gordon Tomaselli
Apr 21, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Polychronis DilaverisChristodoulos Stefanadis
Apr 15, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Frieder BraunschweigLennart Bergfeldt
Nov 13, 2009·Current Opinion in Cardiology·Takeshi Aiba, Gordon F Tomaselli
Apr 25, 2007·Journal of Cardiovascular Electrophysiology·Atul BhatiaMasood Akhtar
Apr 28, 2012·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Roberto A G DouglasCarlos A Pastore
Feb 12, 2010·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Cengizhan TürkoğluInci Firatli
Mar 30, 2007·Congestive Heart Failure·George E MarkBehzad B Pavri

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