Biweekly docetaxel and vinorelbine as first-line chemotherapy in metastatic breast cancer

Clinical Breast Cancer
J I MayordomoA Tres

Abstract

This study was designed to evaluate the antitumor activity and tolerance of biweekly docetaxel plus vinorelbine as first-line chemotherapy in patients with metastatic breast cancer (MBC). Forty-one patients with measurable disease and no prior chemotherapy for MBC were treated with docetaxel 60 mg/m(2) plus vinorelbine 30 mg/m(2) on day 1, every 2 weeks for a maximum of 12 courses. Median age was 58 years (range, 23-75). Fourteen patients (34.1%) were premenopausal and 27 (65.9%) were postmenopausal. Most patients had received prior neoadjuvant/adjuvant chemotherapy (n = 27, 65.9%), radiation therapy (n = 22, 53.6%), and hormone therapy (n = 21, 51.2%). The most frequent sites of metastasis were bone (n = 18, 43.9%), pleuropulmonary (n = 16, 39%), and liver (n = 14, 34.1%). Twenty-seven patients (65.9%) had more than one site of metastasis. Three hundred and thirty-nine courses were given (median, 8 courses per patient; range, 1-12). Median relative dose intensity was 85% for both docetaxel and vinorelbine. Grade 3/4 toxicities included neutropenia (14 patients, 34.1%), febrile neutropenia (n = 14, 34.1%), and stomatitis (n = 4, 9.8%). No treatment-related deaths were reported. All patients were assessed for response in an inte...Continue Reading

Citations

Aug 23, 2005·Expert Review of Anticancer Therapy·Jean-Marc Nabholtz, Joseph Gligorov
Jun 7, 2006·American Journal of Clinical Oncology·Giuseppina SavioBiagio Agostara
Jun 22, 2005·World Journal of Gastroenterology : WJG·Xiao-Ping LiJie Li
May 6, 2008·Anti-cancer Drugs·Xinmiao YangXichun Hu
Jul 4, 2006·Beilstein Journal of Organic Chemistry·Karunananda BombuwalaCarol A Heckman
Nov 22, 2005·Drugs·Katherine A Lyseng-Williamson, Caroline Fenton

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