BK polyomavirus with archetypal and rearranged non-coding control regions is present in cerebrospinal fluids from patients with neurological complications

The Journal of General Virology
Ana Bárcena-PaneroUgo Moens

Abstract

BK polyomavirus (BKPyV) has recently been postulated as an emerging opportunistic pathogen of the human central nervous system (CNS), but it is not known whether specific strains are associated with the neurotropic character of BKPyV. The presence of BKPyV large T-antigen DNA was examined in 2406 cerebrospinal fluid (CSF) samples from neurological patients with suspected JC polyomavirus infection. Twenty patients had a large T-antigen DNA-positive specimen. The non-coding control region (NCCR) of the BKPyV strains amplified from CSF from these 20 patients, strains circulating in renal and bone marrow transplant recipients and from healthy pregnant women was sequenced. The archetypal conformation was the most prevalent in all groups and 14 of the neurological patients harboured archetypal strains, while the remaining six patients possessed BKPyV with rearranged NCCR similar to previously reported variants from non-neurological patients. Transfection studies in Vero cells revealed that five of six early and four of six late rearranged promoters of these CSF isolates showed significantly higher activity than the corresponding archetypal promoter. From seven of the neurological patients with BKPyV DNA-positive CSF, paired serum sam...Continue Reading

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Citations

Jul 15, 2016·Acta Neuropathologica Communications·Armine DarbinyanNadejda M Tsankova
Jul 18, 2015·Cancers·Raquel Burger-Calderon, Jennifer Webster-Cyriaque
Sep 30, 2016·World Journal of Transplantation·Darlene VigilAntonios H Tzamaloukas
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Aug 6, 2020·Viruses·Joan Martí-CarrerasPiet Maes

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