BK viremia is not associated with adverse outcomes in the absence of BK nephropathy

Clinical Transplantation
Amber L Hertz-TangSandesh Parajuli

Abstract

There are limited data regarding the association of different levels of BK viremia and BK nephropathy (BKN), and graft outcomes. We studied the BK plasma PCR levels of all kidney transplant recipients (KTR) transplanted at our institution between 01/01/2006 and 06/30/2014. Patients were divided into groups based on their highest BK plasma PCR level within the first year following transplantation: undetectable, low (<1000 copies/mL), moderate (1000-10 000 copies/mL), high (>10 000-100 000 copies/mL), very high (>100 000 copies/mL), and those that had biopsy-proven BKN. There were a total of 1146 KTR during the study period: 813 with undetectable BK levels and 333 with any detectable BK level (87 with low, 79 with moderate, 88 with high, 34 with very high level BK, and 45 that had BKN). Compared to KTR with an undetectable BK level, incidence of mortality, graft failure, rejections,and infections were not significantly different for those with low, moderate, high, or very high BK level. Patients with BKN had a higher rate of infection and higher rates of total graft failure or death-censored graft failure compared to those with undetectable BK levels. BK viremia in the absence of BKN does not significantly increase the risk of re...Continue Reading

References

Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·D R Snydman
Dec 1, 2001·Transplantation·E MylonakisJ A Fishman
Oct 24, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Solbjørg SagedalHalvor Rollag
Feb 15, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Daniel C BrennanGregory A Storch
Jul 26, 2005·Transplantation·Mieko ToyodaStanley C Jordan
Sep 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Daniel L Bohl, Daniel C Brennan
Nov 29, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jörg BeimlerMartin Zeier
Mar 20, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Aaron Dall, Sundaram Hariharan
Feb 12, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Jesse D ScholdHerwig-Ulf Meier-Kriesche
Apr 28, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Alexander C Wiseman
Sep 3, 2009·Current Opinion in Nephrology and Hypertension·Nina BabelHans-Dieter Volk
Jan 9, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K L HardingerD C Brennan
Jan 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H H HirschUNKNOWN AST Infectious Diseases Community of Practice
Dec 1, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S SchaubM Mayr
Jan 6, 2011·Indian Journal of Nephrology·V Jha
Jul 1, 2011·Clinical Pharmacology and Therapeutics·K BuddeP Glander
Sep 15, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Shamila Karuthu, Emily A Blumberg
Jan 11, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Nissreen ElfadawySherif B Mossad
Sep 27, 2014·Journal of the American Society of Nephrology : JASN·Deirdre SawinskiRoy D Bloom
Nov 9, 2016·Journal of the American Society of Nephrology : JASN·Michael E SeifertDaniel C Brennan
Oct 13, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Andreas GleissGeorg Heinze
Nov 21, 2017·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Johannes KorthOliver Witzke

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Citations

Oct 10, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Caroline MatchettSandesh Parajuli
Jan 6, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Abish KharelSandesh Parajuli
Nov 27, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Isabel BreyerSandesh Parajuli

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