BK virus and immunosuppressive agents

Advances in Experimental Medicine and Biology
Irfan Agha, Daniel C Brennan

Abstract

The last decade has witnessed the introduction of several potent immunosuppressive agents in the field of transplant medicine. Contemporaneously, infection with BK virus (BKV) has emerged as an important complication of immunosuppression and an important cause of allograft loss after kidney transplantation. Rhandhawa et al reported the first case of BKV associated nephropathy (BKVN) in the modern era of transplantation, in 1995. Since then there has been a resurgence of interest in the epidemiology, biology and pathogenic associations of BKV especially in transplant medicine. Up to 90% of adults have serologic evidence of exposure to BKV. However, only 1-5% of normal healthy adults excrete the virus in the urine (asymptomatic viruria). Thus, for a vast majority of the population, the virus remains perfectly latent and this state of latency is of no obvious consequence. Almost all instances of disease by the BKV have been seen in immunocompromised patients. In recent years, BKV has been associated with nephropathy (BKVN) in about 5% of renal transplant patients. Once established, the disease may result in allograft loss in 45-70% of patients. Although not proven by any prospective study, BKVN causing allograft failure has been l...Continue Reading

Citations

Aug 4, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Camila Silva BicalhoLigia Camera Pierrotti
Jun 21, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Andreas O DoeschThomas J Dengler
Jun 19, 2010·Transplantation·Nicolas PalletChristophe Legendre
Mar 26, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Ankur ShahJonathan J Hogan
May 31, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Y J LiY C Tian
Mar 22, 2016·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M MohamedA Djamali

❮ Previous
Next ❯

Related Concepts

Related Feeds

BK Virus Infection

BK virus infection is a significant complication of modern immunosuppression used in kidney transplantation. Discover the latest research on BK virus infection here.

Related Papers

Transplant Infectious Disease : an Official Journal of the Transplantation Society
D Pérez-TorresZ González-Caraballo
Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Corinna SchmittAlbert Heim
© 2022 Meta ULC. All rights reserved