BK virus infection after non-renal transplantation

Advances in Experimental Medicine and Biology
Martha PavlakisDavid K Klassen

Abstract

Infection with BK virus (BKV), a member of the Polyomavirus (PV) family, is ubiquitous, with the virus remaining in a latent form in the kidney and urinary tract. This infection is usually asymptomatic, but with impairment of the cellular immune system the virus can reactivate and lead to tissue damage. In recipients of bone marrow and solid organ transplants, PV reactivation can be associated with disease in urinary tract and kidneys. BKV was first discovered in 1971 from the urine of a kidney transplant recipient who had developed ureteral stenosis 4 months after transplantation. While much of the subsequent research focuses on patients after renal transplantation, we will review PV impact in patients after bone marrow transplant (BMT) and those with non-renal solid organ transplants.

Citations

Dec 19, 2006·Transplantation Proceedings·P D AcottJ F Crocker
Sep 30, 2016·World Journal of Transplantation·Darlene VigilAntonios H Tzamaloukas
Mar 17, 2017·Clinical Microbiology Reviews·George R AmbalathingalRajiv Khanna
Jan 1, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Suman Krishna KotlaRebecca Rojas
Mar 7, 2009·The Journal of General Virology·Johanna R AbendMichael J Imperiale
Jun 19, 2008·Virology·Johanna R Abend, Michael J Imperiale

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