BK virus infection in allogeneic hematopoietic cell transplantation: An update on pathogenesis, immune responses, diagnosis and treatments.

The Journal of Infection
Anastasia SaadeInfectious Disease Working party of EBMT

Abstract

In hematopoietic cell transplantation (HCT) patients, BK polyomavirus (BKPyV) infection results in significant morbidity mainly due to hemorrhagic cystitis (HC). Despite increased knowledge acquired over recent decades, no treatment has shown effectiveness in the management of organ damage in HCT allografts. This review summarizes the current knowledge on BKPyV, from the virus constitution to the pathophysiology and immune-related mechanisms. We next focus on BKPyV-induced HC in HCT to discuss the benefit of monitoring BKPyV viruria and viremia in the management of patients. At last, we review currently used therapeutics, along with future promising therapies to propose clinical and practical guidelines and further interesting research areas.

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Citations

Mar 5, 2021·Annals of Hematology·Małgorzata Salamonowicz-BodziochJan Styczyński
Jun 3, 2021·Microorganisms·Carla PreziosoUgo Moens
Aug 29, 2021·Viruses·Jacek FurmagaAndrzej Jakubczak

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