BK Virus Nephropathy in Heart Transplant Recipients

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Alin JosephLesley A Inker

Abstract

Polyomavirus-associated nephropathy (PVAN) has become an important cause of kidney failure in kidney transplant recipients. PVAN is reported to affect 1% to 7% of kidney transplant recipients, leading to premature transplant loss in approximately 30% to 50% of diagnosed cases. PVAN occurring in the native kidneys of solid-organ transplant recipients other than kidney only recently has been noted. We report 2 cases of PVAN in heart transplant recipients, which brings the total of reported cases to 7. We briefly review the literature on the hypothesized causes of PVAN in kidney transplant recipients and comment on whether these same mechanisms also may cause PVAN in other solid-organ transplant recipients. PVAN should be considered in the differential diagnosis when evaluating worsening kidney function. BK viremia surveillance studies of nonkidney solid-organ recipients should be conducted to provide data to assist the transplantation community in deciding whether regular monitoring of nonkidney transplant recipients for BK viremia is indicated.

References

Dec 1, 2001·Transplantation·E MylonakisJ A Fishman
Aug 16, 2002·The New England Journal of Medicine·Jay A Fishman
Apr 11, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lisa S KellerRandall J Faull
Oct 4, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Betul CelikParmjeet S Randhawa
Dec 26, 2003·The New England Journal of Medicine·Thomas A GonwaGoran B Klintmalm
Aug 5, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C Y William TongJames M Pattison
Jan 25, 2005·Transplantation·Solomon A MenahemJohn P Dowling
Feb 15, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ajit P LimayeMichael Boeckh
Feb 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anskar Y H LeungYok-Lam Kwong
Mar 24, 2005·The New England Journal of Medicine·James W WilliamsMichelle A Josephson
May 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Holger SchmidVolker Kliem
Nov 17, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Patricia MuñozUNKNOWN BKV Study Group
Jun 1, 2006·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J TrofeE Ramos
Jun 1, 2006·Transplant Infectious Disease : an Official Journal of the Transplantation Society·C E H BarberT F Hatchette
Jun 15, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P Randhawa, D C Brennan
Nov 28, 2007·Journal of the American Society of Nephrology : JASN·Roy D Bloom, Peter P Reese
Mar 20, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Aaron Dall, Sundaram Hariharan
Jan 30, 2009·Pediatric Transplantation·S SahneyR Chinnock
Feb 12, 2009·Pediatric Transplantation·Farah N AliRichard A Cohn
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Jan 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H H HirschUNKNOWN AST Infectious Diseases Community of Practice
Jul 30, 2011·Antiviral Research·Biswa Nath SharmaChristine Hanssen Rinaldo
Feb 1, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Belinda T LeeAnil Chandraker
Nov 16, 2014·JAMA : the Journal of the American Medical Association·Greg A KnollJohn S Gill

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Citations

May 26, 2017·Current Opinion in Organ Transplantation·Stephanie G YiKeri E Lunsford
Sep 30, 2016·World Journal of Transplantation·Darlene VigilAntonios H Tzamaloukas
Mar 26, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Ankur ShahJonathan J Hogan
Nov 21, 2017·Clinical Transplantation·Daniel ReichartMarkus Johannes Barten
Nov 13, 2019·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Laura L PetersPrateeti Khazanie
Feb 23, 2021·Clinical Transplantation·Ravi K MallavarapuJohn K Roberts

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