Black brain: transformation of a melanocytoma with diffuse melanocytosis into a primary cerebral melanoma.

Journal of Neuro-oncology
Jens GemptFlorian Ringel

Abstract

We describe here a rare case of the transformation of a supratentorial melanocytoma and diffuse melanocytosis into a primary malignant, CNS melanoma. A 71-year-old woman was admitted after suffering from bulbar speech and dysfunction of fine motor skills for three years. Cerebral imaging revealed an inhomogeneous tumor mass in the right frontal lobe. After craniotomy and opening of the dura, a partially black brain surface was exposed. The solid tumor mass was completely resected. Histopathological workup of the surgical specimen (solid tumor) revealed a melanocytoma with transformation into a malignant melanoma. Three months after surgery, an MR scan was carried out, revealing local tumor recurrence and intracranial spreading. At this time the patient agreed to undergo whole brain radiation therapy, which was carried out. At this date patient has survived 18 months since primary diagnosis with progressive neurological symptoms.

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Citations

Jan 29, 2016·Journal of Korean Neurosurgical Society·Do-Hyoung KimMee Joo
Apr 16, 2013·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Niels A FoitNiklaus Krayenbühl
Dec 30, 2016·Brain Pathology·Lasse DührsenManfred Westphal
Sep 12, 2015·Neurosurgery·Pankaj K AgarwallaJean-Valery Coumans
Feb 6, 2018·Journal of Pediatric Hematology/oncology·Daniel K ChoiRishi R Lulla
Apr 4, 2021·Healthcare·Alfonso MaiellaroGiuseppe Vacchiano

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