Black phosphorus-based 2D materials for bone therapy

Bioactive Materials
Liang ChengWenguo Cui

Abstract

Since their discovery, Black Phosphorus (BP)-based nanomaterials have received extensive attentions in the fields of electromechanics, optics and biomedicine, due to their remarkable properties and excellent biocompatibility. The most essential feature of BP is that it is composed of a single phosphorus element, which has a high degree of homology with the inorganic components of natural bone, therefore it has a full advantage in the treatment of bone defects. This review will first introduce the source, physicochemical properties, and degradation products of BP, then introduce the remodeling process of bone, and comprehensively summarize the progress of BP-based materials for bone therapy in the form of hydrogels, polymer membranes, microspheres, and three-dimensional (3D) printed scaffolds. Finally, we discuss the challenges and prospects of BP-based implant materials in bone immune regulation and outlook the future clinical application.

Citations

Dec 4, 2020·Nanomaterials·Ki-Taek LimJong Hoon Chung
Oct 3, 2020·Bioactive Materials·Ting SuJianliang Shen
Dec 10, 2020·Bioactive Materials·Zhengwei LiXufeng Niu
Apr 16, 2021·ACS Applied Materials & Interfaces·Hui ZhangYuanjin Zhao
Jul 23, 2021·ACS Biomaterials Science & Engineering·Alexander HalimNing-Ping Huang
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Sangheon JeonDong-Wook Han

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