Black rat ( Rattus rattus) genomic variability characterized by chromosome painting

Mammalian Genome : Official Journal of the International Mammalian Genome Society
Pietro CavagnaRoscoe Stanyon

Abstract

Black rats are of outstanding interest in parasitology and infective disease analysis. We used chromosome paints from both the mouse ( Mus musculus) and the Norway rat ( Rattus norvegicus) to characterize the genome of two Black rat subspecies from Italy. Both subspecies have two large metacentrics (n. 1, 4) not present in the Norway rat (2n = 42). Rattus rattus rattus has a diploid number of 2n = 38, while Rattus rattus frugivorous has two small metacentric "supernumerary" or B chromosomes for a diploid number of 2n = 38 + 2B. The 21 mouse paints gave 38 signals on the R. r. rattus karyotype and 39 signals in the R. r. frugivorous karyotype. The two metacentrics, not present in R. norvegicus, were hybridized by mouse 16/1/17 and mouse 4/10/15. These chromosomes are homologous to: RRA1 = RNO 5/7, and RRA4 = RNO 9/11 and not "4/7" and "11/12" as previously reported. Furthermore, the synteny of Chr 13 of the R. r. frugivorous with R. norvegicus Chr 16 and mouse Chrs 8/14 is not complete, because there is a small pericentromeric insertion of RNO Chr 18 (mouse Chr 18). If we consider only the two metacentrics, RRA1 and RRA4, the principal differences between R. norvegicus and R. rattus, then we can propose the derived synteny of 12...Continue Reading

References

Apr 1, 1992·Genes, Chromosomes & Cancer·H TeleniusB A Ponder
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D PinkelJ W Gray
Jan 1, 1974·Chromosoma·A S HendersonK C Atwood
Jan 1, 1997·Cytogenetics and Cell Genetics·J WienbergM A Ferguson-Smith
Feb 20, 1998·Current Opinion in Genetics & Development·J Wienberg, R Stanyon
Jun 29, 1999·Mammalian Genome : Official Journal of the International Mammalian Genome Society·P FinelliJ Wienberg
Jul 15, 1999·International Journal for Parasitology·S MorandA Théron
Feb 16, 2000·The American Journal of Tropical Medicine and Hygiene·A M ZuluetaM Ulrich
Aug 5, 2000·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·S StitouM Burgos
Sep 26, 2000·Mammalian Genome : Official Journal of the International Mammalian Genome Society·P CavagnaR Stanyon

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Citations

Aug 1, 2012·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Raquel ChavesFilomena Adega
Nov 17, 2011·Heredity·S A RomanenkoA S Graphodatsky
Oct 4, 2006·Proceedings. Biological Sciences·Frederic VeyrunesJanice Britton-Davidian
May 17, 2011·BMC Evolutionary Biology·Benoîte CazauxJanice Britton-Davidian
Mar 3, 2007·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Svetlana A RomanenkoAlexander S Graphodatsky
Dec 5, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Svetlana A RomanenkoAlexander S Graphodatsky
Sep 18, 2007·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Taro NakamuraYoichi Matsuda
Feb 23, 2008·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Iris HassStefan Müller
Aug 19, 2011·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Daleen BadenhorstTerence J Robinson
Jun 16, 2012·Cytogenetic and Genome Research·S A Romanenko, V Volobouev
Dec 21, 2007·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Taro NakamuraYoichi Matsuda

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