Black Tea (Camellia sinensis ) Extract Induced Prenatal and Postnatal Toxicity in Experimental Albino rats

Pharmacognosy Magazine
Avijit DeySubir Chandra Dasgupta

Abstract

Tea (Camellia sinensis) being the most widely drank beverage and despite having numerous beneficial role toward health and disease, its safety evaluation during pregnancy and prenatal, postnatal developmental period need to be monitored. This study was to evaluate the toxicity of black tea extract (BTE) in experimental pregnant rats and on their pups during prenatal and postnatal developmental periods. Pregnant female (120 ± 10 g) Wister albino rats were chosen for this study. Group 1 was control group where pregnant female rats were treated with saline. Group 2 and Group 3 were pregnant female rats treated with 50 mg and 100 mg BTE/kg/day, respectively, throughout prenatal and postnatal periods. All three groups of rats were provided food and drinking water ad libitum. Animals were examined through their urinary and serum parameters, histopathological studies, and biomorphometric studies in pups. All data were expressed as mean ± standard deviation with significance between the controls and the treated groups (n = 6). Collected data were subjected to the analysis of variance and Tukey test; P < 0.05 was considered as statistically significant. BTE produced significant alterations in urinary calcium, creatinine, and urea during...Continue Reading

Methods Mentioned

BETA
ELISA
enzyme-linked

Software Mentioned

Motic Images Plus
SPSS

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