Black tea-induced amelioration of hepatic oxidative stress through antioxidative activity in EAC-bearing mice

Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer
Arindam BhattacharyyaTanya Das

Abstract

It is recognized that during cancer, the disease itself as well as many of the anticancer drugs in use produce undesirable side effects such as hepatotoxicity. We have already demonstrated the antitumor and immunorestoring effects of black tea. Here we report Ehrlich's ascites carcinoma (EAC)induced hepatotoxicity and its protection by antitumor dose of black tea in mice. Hepatotoxicity was adjudged by liver histopathology and by measurement of plasma level of alkaline phosphatase (ALP). An attempt to delineate the underlying mechanisms revealed tumor-induced generation of reactive oxygen species (ROS) on one hand and depression in antioxidants that neutralize ROS, i.e., superoxide dismutase (SOD), catalase, reduced glutathione (GSH), and glutathione-S-transferase (GST), on the other. As a result, lipid peroxidation, which leads to damage of host cell components, was increased. Treatment with antitumor dose of black tea could replenish the host's antioxidant system and regress cancer-induced ROS significantly, thereby protecting the host's liver from lipid peroxidation and subsequent degeneration. Thus, unlike many other anticancer agents, black tea not only has antitumor and immunorestoring properties, but it also protects hos...Continue Reading

Citations

Jan 19, 2013·Apoptosis : an International Journal on Programmed Cell Death·Minakshi MazumdarTanya Das
Jan 6, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Xiaoli ChenXiao Ou Shu
Apr 1, 2011·Phytotherapy Research : PTR·Subhra KarmakarChandan Mitra
Jan 9, 2021·Environmental Science and Pollution Research International·Mabrouk Attia Abd EldaimAbdullah A S Ahmed
Jul 6, 2021·The Journal of Nutritional Biochemistry·Sudeshna MukherjeeSreya Chattopadhyay

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