Black titania-based theranostic nanoplatform for single NIR laser induced dual-modal imaging-guided PTT/PDT

Biomaterials
Juan MouJianlin Shi

Abstract

Substantially different from traditional combinatorial-treatment of photothermal therapy (PTT) and photodynamic therapy (PDT) by using multi-component nanocomposite under excitation of separate wavelength, a novel single near infrared (NIR) laser-induced multifunctional theranostic nanoplatform has been rationally and successfully constructed by a single component black titania (B-TiO2-x) for effective imaging-guided cancer therapy for the first time. This multifunctional PEGylated B-TiO2-x shows high dispersity/stability in aqueous solution, excellent hemo/histocompatibility and broad absorption ranging from NIR to ultraviolet (UV). Both in vitro and in vivo results well demonstrated that such a novel multifunctional theranostic nanoplaform could achieve high therapeutic efficacy of simultaneous and synergistic PTT/PDT under the guidance of infrared thermal/photoacoustic (PA) dual-modal imaging, which was triggered by a single NIR laser. This research circumvents the conventional obstacles of using multi-component nanocomposites, UV light and high laser power density. Furthermore, negligible side effects to blood and main tissues could be found in 3 months' investigation, facilitating its potential biomedical application.

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Citations

Jan 27, 2017·ACS Applied Materials & Interfaces·Yi YiWeihong Tan
Mar 25, 2018·Advanced Materials·Hyek Jin KwonTaeghwan Hyeon
Feb 19, 2019·Small·Huijing Xiang, Yu Chen
May 9, 2019·Advanced Healthcare Materials·Minhuan LanPengfei Wang
Jul 23, 2019·Advanced Materials·Bowen YangJianlin Shi
Jul 10, 2019·Lasers in Surgery and Medicine·Yeachan LeeHyun Wook Kang
May 5, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Huaibin ZhangZhong-Xing Jiang
Jun 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Madiha SaeedAiguo Wu
Feb 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qianyun TangXiaochen Dong
Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Atheer Hameid OddaAn-Wu Xu
Aug 31, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ping ZhouShiping Yang
Jun 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Dan YangPiaoping Yang
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Nov 27, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Juan LuPiaoping Yang

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