Blackbody infrared radiative dissociation of bradykinin and its analogues: energetics, dynamics, and evidence for salt-bridge structures in the gas phase

Journal of the American Chemical Society
P D SchnierE R Williams

Abstract

Blackbody infrared radiative dissociation (BIRD) spectra of singly and doubly protonated bradykinin and its analogues are measured in a Fourier-transform mass spectrometer. Rate constants for dissociation are measured as a function of temperature with reaction delays up to 600 s. From these data, Arrhenius activation parameters in the zero-pressure limit are obtained. The activation parameters and dissociation products for the singly protonated ions are highly sensitive to small changes in ion structure. The Arrhenius activation energy (E(a)) and pre-exponential (or frequency factor, A) of the singly protonated ions investigated here range from 0.6 to 1.4 eV and 10(5) to 10(12) s(-1), respectively. For bradykinin and its analogues differing by modification of the residues between the two arginine groups on either end of the molecule, the singly and doubly protonated ions have average activation energies of 1.2 and 0.8 eV, respectively, and average A values of 10(8) and 10(12) s(-1), respectively, i.e., the presence of a second charge reduces the activation energy by 0.4 eV and decreases the A value by a factor of 10(4). This demonstrates that the presence of a second charge can dramatically influence the dissociation dynamics o...Continue Reading

References

Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D F HuntC R Hauer
Nov 1, 1984·Biomedical Mass Spectrometry·P Roepstorff, J Fohlman
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·T D WoodF W McLafferty
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D SuckauF W McLafferty
Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·D S GrossE R Williams
Oct 6, 1989·Science·B F Chmelka, A Pines
Mar 1, 1996·Journal of the American Society for Mass Spectrometry·T YalcinA G Harrison
Nov 1, 1995·Journal of the American Society for Mass Spectrometry·P D SchnierE R Williams
Nov 1, 1994·Journal of the American Society for Mass Spectrometry·K M Downard, K Biemann
Aug 1, 1993·Journal of the American Society for Mass Spectrometry·T Covey, D J Douglas
Jan 1, 1993·Journal of the American Society for Mass Spectrometry·L L Griffin, D J McAdoo
Jun 1, 1993·Journal of the American Society for Mass Spectrometry·K D Ballard, S J Gaskell

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Citations

Sep 15, 2000·Mass Spectrometry Reviews·M T Rodgers, P B Armentrout
Nov 30, 2002·Chemistry : a European Journal·Brigitte S FoxVladimir E Bondybey
Apr 12, 2002·Mass Spectrometry Reviews·C A Schalley
Jul 3, 2003·Mass Spectrometry Reviews·Julia Laskin, Jean H Futrell
May 28, 2003·Mass Spectrometry Reviews·Roman A Zubarev
Dec 26, 2001·Rapid Communications in Mass Spectrometry : RCM·H Wincel, R H Fokkens
Jul 12, 2002·Rapid Communications in Mass Spectrometry : RCM·Peter B O'Connor
Sep 6, 2007·Analytical and Bioanalytical Chemistry·E D RaczyńskaM Szelag
Feb 23, 2012·Journal of the American Society for Mass Spectrometry·Benjamin J BythellAlan G Marshall
Apr 6, 2012·Journal of the American Society for Mass Spectrometry·Owen S SkinnerKathrin Breuker
Mar 7, 2013·Journal of the American Society for Mass Spectrometry·Ian K WebbScott A McLuckey
Sep 1, 1996·Journal of the American Society for Mass Spectrometry·P D SchnierE R Williams
Dec 4, 2003·Journal of the American Society for Mass Spectrometry·John C JurchenEvan R Williams
Feb 10, 2004·Journal of the American Society for Mass Spectrometry·Richard L Beardsley, James P Reilly
Jul 6, 2004·Journal of the American Society for Mass Spectrometry·Andrew S Lemoff, Evan R Williams
Nov 3, 2004·Journal of the American Society for Mass Spectrometry·Aleksey V TolmachevRichard D Smith
May 26, 2005·Journal of the American Society for Mass Spectrometry·Richard L WongDavid E Clemmer
Jul 22, 2006·Journal of the American Society for Mass Spectrometry·Liangyi ZhangJames P Reilly
Apr 10, 2007·Journal of the American Society for Mass Spectrometry·Yi-Min SheJohn B Westmore
Mar 8, 2008·Journal of the American Society for Mass Spectrometry·Liangyi Zhang, James P Reilly
Dec 6, 2008·Journal of the American Society for Mass Spectrometry·Khadijeh RajabiTravis D Fridgen
Sep 15, 2009·Journal of the American Society for Mass Spectrometry·Yiqun HuangDavid H Russell
Apr 23, 2010·Journal of the American Society for Mass Spectrometry·Jeong Hee MoonMyung Soo Kim
May 21, 2010·Journal of the American Society for Mass Spectrometry·Tae-Young KimJames P Reilly
Jul 7, 2000·Journal of the American Society for Mass Spectrometry·S J ShieldsD H Russell
Feb 24, 2001·Journal of the American Society for Mass Spectrometry·I K ChuK W Siu
Jul 11, 2001·Journal of the American Society for Mass Spectrometry·B B SchneiderD D Chen
Jan 5, 2002·Journal of the American Society for Mass Spectrometry·A S Danell, G L Glish
Jun 12, 2002·Journal of the American Society for Mass Spectrometry·Ethan R BadmanDavid E Clemmer
Feb 15, 2003·Journal of the American Society for Mass Spectrometry·Dunmin Mao, D J Douglas
May 1, 1997·Journal of the American Society for Mass Spectrometry·D S GrossE R Williams
Aug 6, 1998·Journal of the American Society for Mass Spectrometry·A E CountermanD E Clemmer
Oct 30, 1998·Journal of the American Society for Mass Spectrometry·J S KlassenE R Williams
Sep 25, 1999·Journal of the American Society for Mass Spectrometry·N P wing, C J Cassady
Oct 28, 1999·Journal of the American Society for Mass Spectrometry·S J ValentineD E Clemmer
Oct 28, 1999·Journal of the American Society for Mass Spectrometry·E F StrittmatterE R Williams
Feb 26, 2000·Journal of the American Society for Mass Spectrometry·T G SchaaffS A McLuckey
Aug 10, 2012·Chemical Reviews·Michael Meot-Ner Mautner
Sep 8, 2012·Journal of the American Chemical Society·Terrence M ChangEvan R Williams
Feb 5, 2013·Journal of the American Chemical Society·Nicholas A PiersonDavid E Clemmer
Jul 25, 2009·Journal of the American Chemical Society·James S PrellEvan R Williams

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