blaCMY-2-positive IncA/C plasmids from Escherichia coli and Salmonella enterica are a distinct component of a larger lineage of plasmids.

Antimicrobial Agents and Chemotherapy
Douglas R CallThomas E Besser

Abstract

Large multidrug resistance plasmids of the A/C incompatibility complex (IncA/C) have been found in a diverse group of Gram-negative commensal and pathogenic bacteria. We present three completed sequences from IncA/C plasmids that originated from Escherichia coli (cattle) and Salmonella enterica serovar Newport (human) and that carry the cephamycinase gene blaCMY-2. These large plasmids (148 to 166 kbp) share extensive sequence identity and synteny. The most divergent plasmid, peH4H, has lost several conjugation-related genes and has gained a kanamycin resistance region. Two of the plasmids (pAM04528 and peH4H) harbor two copies of blaCMY-2, while the third plasmid (pAR060302) harbors a single copy of the gene. The majority of single-nucleotide polymorphisms comprise nonsynonymous mutations in floR. A comparative analysis of these plasmids with five other published IncA/C plasmids showed that the blaCMY-2 plasmids from E. coli and S. enterica are genetically distinct from those originating from Yersinia pestis and Photobacterium damselae and distal to one originating from Yersinia ruckeri. While the overall similarity of these plasmids supports the likelihood of recent movements among E. coli and S. enterica hosts, their greater...Continue Reading

References

Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Jun 1, 1994·Journal of Bacteriology·C LlanesY Michel-Briand
Jan 1, 1996·Antimicrobial Agents and Chemotherapy·A BauernfeindH Giamarellou
Sep 8, 1999·Microbiology and Molecular Biology Reviews : MMBR·C A LiebertA O Summers
Nov 11, 1999·Nucleic Acids Research·A L DelcherS L Salzberg
Dec 20, 2000·Bioinformatics·K RutherfordB Barrell
Dec 26, 2001·Antimicrobial Agents and Chemotherapy·Alain PhilipponGeorge A Jacoby
Dec 26, 2001·Bioinformatics·B E SuzekS L Salzberg
Apr 18, 2002·Antimicrobial Agents and Chemotherapy·Miriam Barlow, Barry G Hall
Jun 28, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R OdehJ P Quinn
Aug 19, 2003·Current Issues in Molecular Biology·Alessandra Carattoli
Jul 27, 2004·Antimicrobial Agents and Chemotherapy·W P GilesP D Fey
Jun 28, 2005·Antimicrobial Agents and Chemotherapy·Martine BraibantAxel Cloeckaert
Jul 14, 2006·Emerging Infectious Diseases·Alessandra CarattoliGian Maria Rossolini
Oct 13, 2006·Veterinary Microbiology·Margaret A DavisDouglas R Call
Mar 22, 2007·PloS One·Timothy J WelchJacques Ravel
May 10, 2007·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Aug 20, 2008·Antimicrobial Agents and Chemotherapy·Jing-Cao PanZhe-Sheng He
May 13, 2009·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Yeon-Joon ParkHyo-Sun Kwak

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Citations

Apr 6, 2013·Plasmid·Jaroslaw E KrólEva M Top
Aug 14, 2010·Foodborne Pathogens and Disease·Maria Sjölund-KarlssonJean M Whichard
Sep 3, 2011·Foodborne Pathogens and Disease·Jason P FolsterJean M Whichard
Sep 19, 2012·Foodborne Pathogens and Disease·Tim C Boyer, Randall S Singer
Jul 10, 2012·The Journal of Antimicrobial Chemotherapy·Benoît DoubletMichael R Mulvey
Jul 17, 2010·Antimicrobial Agents and Chemotherapy·Mark A Toleman, Timothy R Walsh
Nov 2, 2012·Antimicrobial Agents and Chemotherapy·Anaïs PotronLaurent Poirel
Oct 17, 2012·Antimicrobial Agents and Chemotherapy·Carmelo S Del CastilloTakashi Aoki
Feb 27, 2013·Antimicrobial Agents and Chemotherapy·Min-Su KangJun-Hun Kwon
Oct 26, 2011·Antimicrobial Agents and Chemotherapy·Sandra K UrichJeannine M Petersen
Nov 30, 2011·Antimicrobial Agents and Chemotherapy·Alessandra CarattoliPatrice Nordmann
Dec 7, 2011·Antimicrobial Agents and Chemotherapy·Laurent PoirelPatrice Nordmann
May 1, 2012·Applied and Environmental Microbiology·Dixie F MollenkopfThomas E Wittum
Aug 16, 2011·Applied and Environmental Microbiology·Rebecca L LindseyRichard J Meinersmann
Jun 12, 2013·Applied and Environmental Microbiology·R J MeinersmannB B Oakley
May 24, 2011·Applied and Environmental Microbiology·Murugan SubbiahDouglas R Call
Dec 14, 2011·Applied and Environmental Microbiology·Laura C MartinPatrick Boerlin
Feb 22, 2012·Applied and Environmental Microbiology·Kevin S LangTimothy J Johnson
Mar 20, 2013·Advances in Bioinformatics·Yunyun ZhouShira L Broschat
Jul 24, 2014·International Journal of Antimicrobial Agents·Hanna E SidjabatDavid L Paterson
Jun 9, 2014·The Journal of Antimicrobial Chemotherapy·Likou ZouShaohua Zhao
May 21, 2014·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Christopher J Harmer, Ruth M Hall
Oct 24, 2014·Emerging Infectious Diseases·Jason P FolsterJean M Whichard
Sep 23, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C ChouchaniT R Walsh
Sep 14, 2010·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Maria S Ramirez, Marcelo E Tolmasky
Mar 10, 2016·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Getahun E AggaTerrance M Arthur

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