Bladder augmentation in the prevention of cyclophosphamide-induced haemorrhagic cystitis in the rat model

British Journal of Urology
L E CrocittoT G Wilson

Abstract

To evaluate the effects of cyclophosphamide on the bowel mucosa of the rat and to determine whether urothelium can be protected from the effects of haemorrhagic cystitis which can occur after treatment with cyclophosphamide. Thirty Sprague-Dawley rats were divided into three groups, 10 undergoing a control (sham) operation, 10 an ileal bladder augmentation and 10 a colonic bladder augmentation. Each rat underwent the appropriate surgical procedure and after a recovery period of 2 weeks, was injected with cyclophosphamide. Urine specimens were collected 24 h after the injection and analysed for gross and microscopic haematuria. The rats were killed humanely 48 h after injection and the bladders examined for haemorrhage, oedema, attenuation, inflammation and erosion. None of the 20 augmented rats developed gross haematuria and only four developed microscopic haematuria, compared with the control rats where six of 10 developed gross haematuria and nine developed microscopic haematuria. In addition, the control rats had moderate to severe haemorrhage, oedema and attenuation compared with only mild changes in the augmented rats. This protection was significant for both the bowel mucosa and urothelium. It is possible that the adminis...Continue Reading

Citations

Aug 8, 2001·BJU International·C Kouriefs, S J Gordon
Oct 3, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Hisae NishiiTetsuro Matsumoto
Dec 15, 2007·The American Journal of Pathology·Magaly Martinez-FerrerNeil A Bhowmick

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