Bladder cancer detection in patients with gross haematuria: Computed tomography urography with enhancement-triggered scan versus flexible cystoscopy

Scandinavian Journal of Urology
Malin HeleniusAnders Magnusson

Abstract

Computed tomography urography (CTU) can be used to direct further investigation of patients if the bladder tumour detection rate is high. The aim of this study was to compare a CTU protocol including an enhancement-triggered scan and flexible cystoscopy for detecting bladder tumours. Patients with gross haematuria undergoing CTU during 2005-2008 were included. For patients younger than 50 years the CTU protocol included unenhanced, enhancement-triggered corticomedullary, and excretory phases. Patients older than 50 years followed the same protocol plus a nephrographic phase. The entire urinary tract was examined in all phases. Of 435 patients, 55 patients were diagnosed with bladder tumour. CTU detected bladder tumour in 48 patients (87%). Five CTU examination reports were false positive. With CTU, sensitivity for finding bladder tumour was 0.87, specificity 0.99, positive predictive value (PPV) 0.91 and negative predictive value (NPV) 0.98. Cystoscopy detected bladder tumour in 48 patients (87%) and had one false-positive finding, resulting in sensitivity of 0.87, specificity 1.0, PPV 0.98 and NPV 0.98. The detection rate of bladder tumours for the CTU protocol including an enhancement-triggered scan was high and comparable to...Continue Reading

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Citations

Sep 4, 2015·The Journal of Urology·Kim E M van KesselWim Van Criekinge
Jan 16, 2016·Disease Markers·Hiroki Ide, Hiroshi Miyamoto
Jun 28, 2016·Lancet·Ashish M KamatWassim Kassouf
Mar 6, 2019·Journal of Cellular Physiology·Mohammad SarfiEhsan Khalili
May 26, 2017·Scandinavian Journal of Urology·Per-Uno MalmströmGregers G Hermann
Sep 20, 2020·Diagnostics·Samuel J GalganoSoroush Rais-Bahrami
Nov 21, 2018·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·Ebru SalmanogluMathew L Thakur
Oct 11, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shuxiong ZengChuanliang Xu
Jun 15, 2021·The Cochrane Database of Systematic Reviews·Mi Ah HanPhilipp Dahm
Oct 28, 2021·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Natalia GrubaAdam Lesner

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