Bladder cancer risks in workers manufacturing chemicals for the rubber industry

Occupational Medicine
T Sorahan

Abstract

To investigate bladder cancer risks in workers from a factory manufacturing chemicals for the rubber industry. The mortality (1955-2005) and cancer morbidity experience (1971-2005) of a cohort of 2160 male production workers from a chemical factory in north Wales were investigated. Exposure estimates (or surrogates) were developed for four chemicals: 2-mercaptobenzothiazole (MBT), aniline, phenyl-beta-naphthylamine (PBN) and ortho-toluidine. Two analytical approaches were used, indirect standardization and Poisson regression. Based on mortality rates for the general population, there was a statistically significant (P < 0.01) excess mortality from bladder cancer in the 611 study subjects potentially exposed to one or more of the four chemicals being investigated (observed 11, standardized mortality ratio 278, 95% confidence interval 139-497). There was no excess bladder cancer mortality in the remaining 1555 workers. A similar contrast was also shown for bladder cancer incidence. There were 56 study subjects who had suffered from bladder cancer (malignant or benign). In simultaneous analyses of the four exposure history variables, Poisson regression showed a significant positive trend for bladder cancer risk in relation to cumu...Continue Reading

References

Apr 3, 1991·Journal of the National Cancer Institute·E WardW Halperin
Jan 1, 1988·International Archives of Occupational and Environmental Health·M J Stasik
Mar 1, 1986·International Journal of Epidemiology·M ColemanJ Peto
Oct 1, 1993·British Journal of Industrial Medicine·M E StraussR M Bannister
Nov 1, 1993·British Journal of Industrial Medicine·T Sorahan, D Pope
Feb 5, 2000·Occupational and Environmental Medicine·J J CollinsS G Riordan
Aug 5, 2000·Occupational and Environmental Medicine·C A Veys
Apr 15, 2008·The Lancet Oncology·Robert BaanUNKNOWN WHO Intrnational Agency for Research on Cancer Monograph Working Group

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Citations

Jul 30, 2011·Journal of Toxicology and Environmental Health. Part a·Gary GinsbergTara Kurland
Jun 20, 2012·Journal of Occupational and Environmental Hygiene·Kevin W HanleyAvima M Ruder
Nov 17, 2009·Neurological Research·Pengfei GeYinan Luo
Sep 4, 2012·Regulatory Toxicology and Pharmacology : RTP·J Caroline EnglishClifton J McLellan
Oct 22, 2013·Occupational and Environmental Medicine·Robert D DanielsLynne E Pinkerton
Feb 24, 2015·Analytical and Bioanalytical Chemistry·Wolfgang GriesGabriele Leng
Apr 17, 2013·Nature Reviews. Urology·Iawen HsuShuyuan Yeh
May 12, 2016·World Journal of Hepatology·Venerando RapisardaGaetano Bertino
Dec 22, 2016·Molecular Medicine Reports·Caterina LeddaVenerando Rapisarda
Sep 27, 2018·Journal of Cellular and Molecular Medicine·Mengting DingZhiming Cai
May 11, 2020·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yonggang QiRui-Sheng Wang
Mar 3, 2021·International Archives of Occupational and Environmental Health·Makiko NakanoToru Takebayashi
Mar 27, 2018·Environmental Science & Technology·Chunyang LiaoKurunthachalam Kannan
Nov 18, 2021·Environmental Science & Technology·Emily B FranklinAllen H Goldstein

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