Bladder-conserving surgery and interstitial brachytherapy for lymph node negative transitional cell carcinoma of the urinary bladder: results of a 28-year single institution experience

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Renaud de CrevoisierChristine Haie-Meder

Abstract

We retrospectively analyzed results for lymph node negative transitional cell carcinoma of the bladder treated with brachytherapy. From 1975-2002, 58 patients received preoperative external irradiation, partial cystectomy (in 69%), iliac node dissection, and iridium-192. Pathologic stage was: 10 pT1, 41 pT2, and 7 pT3. A median total brachytherapy dose of 60 Gy was delivered to the tumor bed. Mean follow-up was 76 months (range, 0.5-296). Tumor stage significantly impacted cause-specific and disease-free survival (P=0.02). Eight pT1 patients were free of disease and 2 died of other cause. For pT2 patients, 5-year cause-specific and overall survival rates were, respectively, 70% (CI 95%: 53-87) and 60% (CI 95%: 43-77). Three pT3 patients died of cancer. For the pT2 patients, the probability of 5-year local control was 65% (CI 95%: 47-83) and being alive without disease with a functional bladder, 50% (CI 95%: 33-67). Previous transurethral resection (TUR) increased the bladder relapse risk among pT2 patients (P=0.03). Twelve patients had severe acute complications and 5 had severe late effects. A high dose of external irradiation increased risk of late complications (P=0.01). Most complications occurred in patients treated before...Continue Reading

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Citations

May 22, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Elzbieta van der Steen-BanasikAndries G Visser
Jun 15, 2016·International Journal of Radiation Oncology, Biology, Physics·Elzbieta M van der Steen-BanasikAndries G Visser
Jan 5, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Bradley R PietersErik Van Limbergen
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Sep 5, 2008·Nature Clinical Practice. Urology·Mohamed A Ghoneim, Hassan Abol-Enein
Aug 24, 2013·The Cochrane Database of Systematic Reviews·Mao Ling WeiYanming Mu

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