Bladder contractility index in posterior urethral valve: A new marker for early prediction of progression to renal failure

Journal of Pediatric Urology
M S AnsariPriyank Yadav

Abstract

Posterior urethral valve (PUV) is the most common cause of pediatric end stage renal disease (ESRD), imposing a major health burden on medical community caregivers and adversely affecting the quality of life of patients. Chronic kidney disease (CKD) stage III or estimated GFR of <60 mL/min/1.73 m2 is known to be associated with more adverse renal, cardiovascular, and clinical outcomes. Thus, it is desirable to identify factors predicting the rapid and early progression of disease. In the present study, baseline characteristics and urodynamic study (UDS) parameters of boys with PUV are correlated with CKD progression to IIIB or more. To study the correlation of bladder contractility index (BCI) with development of CKD stage IIIB (eGFR of <45 mL/min/1.73 m2) or more in boys with PUV. Baseline characteristics and demographical variables of 270 boys with PUV who underwent valve fulguration at the hospital between 2000 and 2010 were recorded and certain UDS parameters in follow-up were noted such as bladder contractility index (BCI = PdetQmax + 5 Qmax), end filling pressure (EFP), compliance (ΔC), bladder outlet obstruction index (BOOI = Pdet Qmax - 2 Qmax), and bladder volume efficiency (BVE = Voided volume/total capacity). Fate of...Continue Reading

Citations

Apr 16, 2020·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Liang-Feng TangAn-Le Wang
Apr 7, 2019·Current Urology Reports·Temitope RudeDavid Ginsberg
Dec 7, 2020·Journal of Pediatric Urology·Poonam Guha VazeSushmita Banerjee

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