Bladder dysfunction in rats with metabolic syndrome induced by long-term fructose feeding

The Journal of Urology
Wei-Chia LeeShih-Wei Lee

Abstract

We studied the effects of long-term fructose feeding and metabolic perturbations on bladder function in rats. Female Wistar rats were fed a fructose enriched (60%) or control diet for 3 and 6 months. In vitro contractile responses to electrical field stimulation, KCl, carbachol and adenosine triphosphate, and in vivo cystometry were used to evaluate bladder function. Tissue staining and electron microscopy were also performed to evaluate the structural changes in rats subjected to metabolic syndrome. Biochemical and physiological data were compared between fructose fed rats and age matched controls. All rats fed a fructose enriched diet for 3 months showed insulin resistance, hyperinsulinemia, hypertriglyceridemia and hypertension. These fructose fed rats showed a decreased contractile response to high concentrations of KCl but not to other parameters tested compared to controls. Eight of the 12 rats (66.7%) showed abnormal cystometry, mainly by increased phasic contractions. In 6-month fructose fed rats contractile responses to electrical field stimulation, KCl and carbachol were decreased significantly. However, responsiveness to high concentrations of adenosine triphosphate was significantly increased. Morphological studies ...Continue Reading

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Citations

Mar 13, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Annamaria MorelliMario Maggi
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