Bladder neck invasion is an independent predictor of prostate-specific antigen recurrence

Cancer
Christopher K PoulosLiang Cheng

Abstract

The 1997 TNM staging system for prostatic carcinoma and the 2002 revision thereof classified prostatic carcinoma with bladder neck involvement classified as pT4 disease. This classification is based on the belief that tumors that invade surrounding structures are more aggressive and warrant higher staging than tumors that do not invade surrounding structures. Recent reports in the literature suggested that microscopic involvement of the bladder neck does not carry independent prognostic significance. Therefore, resection specimens with bladder neck involvement should not be classified as pT4. The current study prospectively examined the prognostic significance of bladder neck involvement by prostatic carcinoma. The authors analyzed the totally embedded and whole-mounted radical prostatectomy specimens from 364 consecutive patients. The mean patient age was 66 years (range, 41-77 years). The bladder neck, which had been coned from the specimen, was cut in a perpendicular fashion. Involvement of the bladder neck was defined as the presence of neoplastic cells within the smooth muscle bundles of the coned bladder neck. The data were prospectively collected. Bladder neck involvement was analyzed in relation to age, preoperative pro...Continue Reading

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Citations

Jun 20, 2008·International Urology and Nephrology·Thais RuanoAthanase Billis
Dec 2, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ming ZhouCristina Magi-Galluzzi
Aug 24, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Puay Hoon TanUNKNOWN ISUP Prostate Cancer Group
Aug 31, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Cristina Magi-GalluzziUNKNOWN ISUP Prostate Cancer Group
Sep 14, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hemamali SamaratungaUNKNOWN ISUP Prostate Cancer Group
Oct 12, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Chistopher K PoulosLiang Cheng
Sep 19, 2007·Prostate Cancer and Prostatic Diseases·F Rodriguez-CovarrubiasL Salomon
Sep 29, 2005·Journal of Clinical Pathology·R E EmersonL Cheng
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