Bladder recovery by stem cell based cell therapy in the bladder dysfunction induced by spinal cord injury: systematic review and meta-analysis

PloS One
Jae Heon KimYun Seob Song

Abstract

Bladder dysfunction induced by spinal cord injury (SCI) can become problematic and severely impair the quality of life. Preclinical studies of spinal cord injury have largely focused on the recovery of limb function while neglecting to investigate bladder recovery. The present study was performed to investigate and review the effect of stem cell-based cell therapy on bladder recovery in SCI. We conducted a meta-analysis of urodynamic findings of experimental trials that included studies of stem cell-based cell therapy in SCI. Relevant studies were searched using MEDLINE, EMBASE and Cochrane Library (January 1990 - December 2012). Final inclusion was determined by a urodynamic study involving detailed numerical values. Urodynamic parameters for analysis included voiding pressure, residual urine, bladder capacity and non-voiding contraction (NVC). Meta-analysis of the data, including findings from urodynamic studies, was performed using the Mantel-Haenszel method. A total of eight studies were included with a sample size of 224 subjects. The studies were divided into different subgroups by different models of SCI. After a stem cell-based cell therapy, voiding pressure (-6.35, p <0.00001, I2 = 77%), NVC (-3.58, p <0.00001, I2 = 82...Continue Reading

References

Mar 1, 1979·ARN Journal : the Official Journal of the Association of Rehabilitation Nurses·S R BetterE N Owen
Sep 1, 1984·The Journal of Urology·B Uvelius, A Mattiasson
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·F H GageJ Ray
Jan 14, 1998·Urology·W C de Groat
Nov 24, 1999·Urology·M YoshiyamaM B Chancellor
Feb 26, 2000·Science·F H Gage
Feb 7, 2001·Brain : a Journal of Neurology·B S AthwalC J Fowler
Jan 24, 2002·The Journal of Pharmacology and Experimental Therapeutics·Victor Pikov, Jean R Wrathall
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·C P HofstetterL Olson
May 26, 2004·Neuroscience Letters·Masayoshi TsuruokaTomio Inoue
Nov 13, 2004·Annals of Biomedical Engineering·Jiro NagatomiMichael S Sacks
Jan 28, 2005·Journal of Neurotrauma·Kim D Anderson
Oct 11, 2005·Neuro-Signals·Robert P Yezierski
Mar 31, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Soheila Karimi-AbdolrezaeeMichael G Fehlings
Jul 22, 2006·Nature Reviews. Neuroscience·Sandrine ThuretFred H Gage
Oct 23, 2008·Journal of Neurosurgery. Spine·Birgit NeuhuberItzhak Fischer
Aug 25, 2009·Obstetrics and Gynecology·Matthew D BarberUNKNOWN Pelvic Floor Disorders Network
Apr 12, 2011·Current Stem Cell Research & Therapy·Joaquim HernándezXavier Navarro

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Citations

Jun 17, 2015·Korean journal of urology·Jae Heon Kim, Yun Seob Song
Jan 23, 2019·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·He ZhaoXing Yu
Oct 7, 2020·International Neurourology Journal·Hanieh Salehi-PourmehrSaeed Sadigh-Eteghad
Apr 9, 2021·Expert Opinion on Biological Therapy·William Brett McIntyreMichael G Fehlings

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Methods Mentioned

BETA
ELISA

Software Mentioned

Emtree
Comprehensive Meta - Analysis
Review Manager

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