Bladder reduction surgery accelerates the appearance of spontaneous voiding in neonatal rats

The Journal of Urology
Yuen-Keng NgChung Kwong Yeung

Abstract

Patients with nocturnal enuresis may have small functional bladder capacity or altered bladder fullness sensation. We determined whether reducing bladder volume would affect the central inhibition of voiding that is normally present between birth and 2 weeks of life in neonatal rats. One and 3-week-old Sprague-Dawley rats underwent 50% bladder volume reduction by suture closure of the bladder dome. T8-T10 spinal cord injury was done in select animals. Latency of the perigenital-bladder reflex, spontaneous voiding onset and body weight were measured. Cystometry using urethane anesthesia, and measurements of in vitro spontaneous and KCl evoked contractions were done. Bladder reduction surgery led to the immediate appearance of spontaneous voiding in 1-week-old rats. Cystometry at 2 weeks showed voiding contractions in rats with bladder reduction, which was abolished by acute T8-T10 spinalization. Voiding contractions were not seen in animals with sham surgery or concurrent T8-T10 spinalization and bladder reduction. The perigenital-bladder reflex, somatic growth, spontaneous bladder contractions and bladder contractility were not affected by bladder reduction. Bladder capacity at 9 weeks was significantly larger in animals that u...Continue Reading

References

Aug 1, 1989·The Journal of Urology·A T LinR M Levin
Jun 25, 1998·Behavioural Brain Research·W C de GroatJ R Roppolo
Feb 14, 2006·The Journal of Urology·Hsi-Yang Wu, William C de Groat
May 20, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yuen-Keng NgHsi-Yang Wu
Jul 4, 2006·The Journal of Pain : Official Journal of the American Pain Society·Alan RandichTimothy J Ness
Jan 20, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yuen-Keng NgHsi-Yang Wu
Jul 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth RickenbacherRita J Valentino

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Citations

Mar 20, 2010·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Johan Van de WalleAnn Raes
Jun 10, 2010·Nature Reviews. Urology·Hsi-Yang Wu

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