Bladder wall biomechanics: A comprehensive study on fresh porcine urinary bladder

Journal of the Mechanical Behavior of Biomedical Materials
Maryam Sami JokandanIoannis S Chronakis

Abstract

Regenerative medicine for reconstructive urogenital surgery has been widely studied during the last two decades. One of the key factors affecting the quality of bladder regeneration is the mechanical properties of the bladder scaffold. Insight into the biomechanics of this organ is expected to assist researchers with functional regeneration of the bladder wall. Due to extensive similarities between human bladder and porcine bladder, and with regard to lack of comprehensive biomechanical data from the porcine bladder wall (BW), our main goal here was to provide a thorough evaluation on viscoelastic properties of fresh porcine urinary BW. Three testing modes including Uniaxial tensile, ball-burst (BB) and Dynamic Mechanical Analysis (DMA) were applied in parallel. Uniaxial tests were applied to study how different circumferential and longitudinal cut-outs of lateral region of BW behave under load. DMA was used to measure the viscoelastic properties of the bladder tissue (storage and loss modulus) in a frequency range of 0.1-3Hz. BB was selected as a different technique, replicating normal physiological conditions where the BW is studied in whole. According to uniaxial tests, the anisotropic behavior of bladder is evident at strai...Continue Reading

Citations

Feb 13, 2018·Nature Reviews. Urology·Fatemeh AjalloueianMagdalena Fossum
Dec 22, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Amanda Schmidt, David Taylor
Dec 29, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Robin TrostorfMarkus Böl
Mar 2, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Sanaz KhademolqoraniFatemeh Ajalloueian
Mar 23, 2021·Journal of Medical Engineering & Technology·Andrew GammieMarcus J Drake
Sep 30, 2021·Biomedical Materials·Gurpreet Singh, Arnab Chanda
Jan 4, 2022·International Urology and Nephrology·Jianli WangBing Li

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