Blastic natural killer (NK)-cell lymphoma: report of an unusual CD4 negative case and review of the CD4 negative neoplasms with blastic features in the literature

Leukemia & Lymphoma
Theodore ArgyrakosP Kanavaros

Abstract

Blastic Natural Killer (NK)-cell lymphoma is a relatively new entity which has been recently included in the WHO classification. CD4 expression is observed in most cases of blastic NK-cell lymphomas and has been related with skin tropism. We report an unusual CD4 negative blastic NK-cell lymphoma with primary presentation in the skin, subsequent infiltration of the bone marrow and aggressive behavior. It is emphasized that extensive immunophenotyping and EBER RNA in situ hybridization are required in order to establish the diagnosis of blastic NK-cell lymphoma. We also present a review of the literature with respect to the CD4 negative NK-cell lymphomas with blastic morphological features.

References

Oct 23, 1997·The American Journal of Surgical Pathology·J A DiGiuseppeM J Borowitz
May 5, 1998·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·M BabaS Baba
Sep 16, 1999·Cellular Immunology·C J OngH S Teh
Nov 28, 2001·Hematology·J P GreerT P Loughran
Jul 20, 2002·Leukemia Research·Roberto P FalcãoNorma T Foss
Jul 26, 2002·British Journal of Haematology·Junjiro TsuchiyamaMine Harada
Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takako HirataBruce Furie
Oct 23, 2002·Leukemia & Lymphoma·T TouahriC Fourcade
Jan 28, 2003·Cancer·Marco SantucciUNKNOWN EORTC Cutaneous Lymphoma Task Force
Sep 2, 2003·American Journal of Hematology·Michael ShapiroStephen J Schuster
Sep 26, 2003·The American Journal of Surgical Pathology·Kennosuke KarubeMasahiro Kikuchi

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Citations

Nov 9, 2012·Annals of Hematology·Ho Jung AnCheolwon Suh
Dec 1, 2011·The American Journal of Dermatopathology·Angel Fernandez-Flores
Jan 7, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nikhil A SangleMohamed E Salama
Feb 18, 2012·American Journal of Clinical Pathology·Danielle M P CroninUma N Sundram
May 23, 2008·Journal of Cutaneous Pathology·Stefano AscaniLorenzo Cerroni
Jun 16, 2010·Annals of Dermatology·Kyu-Won ChoiKi-Ho Kim

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