Blastic phase of chronic myelogenous leukemia.

Current Treatment Options in Oncology
Merat Karbasian EsfahaniPeter H Wiernik

Abstract

Chronic myelogenous leukemia (CML), also known as chronic myelocytic or chronic myeloid leukemia, is a clonal disorder of hematopoiesis that arises in a hematopoietic stem cell or early progenitor cell. This is characterized by the dysregulated production of mature nonlymphoid cells with normal differentiation. Eventually, in spite of the term chronic, there is progression to acute leukemia, usually of the myeloid variety, which is highly resistant to current therapies. Despite recent improvements in the treatment of early-stage disease, CML blast crisis (CMLBC) remains a therapeutic challenge. CMLBC is highly refractory to standard induction chemotherapy, with a response rate in myeloid blast crisis of less than 30%. Conventional chemotherapy has been much less successful in this disease compared with de novo acute leukemia, with a mean survival after diagnosis of blast crisis of only 2 to 4 months for nonresponders. Many regimens of chemotherapies have been tried in CMLBC, with minor success. Although imatinib was evaluated in patients with CMLBC, most CMLBC cases today arise in patients already on imatinib-based therapy and developing blastic phase on that therapy; thus there is no standard therapy for patients with CMLBC. F...Continue Reading

References

Mar 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H M KantarjianA Deisseroth
Sep 1, 1987·The American Journal of Medicine·H M KantarjianE J Freireich
Jan 23, 1986·The New England Journal of Medicine·J M GoldmanJ Hows
Nov 1, 1996·Leukemia Research·G SpecchiaV Liso
May 14, 1999·Trends in Cell Biology·R A Van Etten
Jul 31, 1999·Annals of Internal Medicine·S FaderlH M Kantarjian
Jan 5, 2000·The Journal of Clinical Investigation·B J Druker, N B Lydon
Jun 12, 2002·Current Treatment Options in Oncology·J P Dutcher, P H Wiernik
Oct 3, 2002·British Journal of Haematology·Anne S TsaoMoshe Talpaz
May 21, 2003·Annals of Internal Medicine·Razelle KurzrockMoshe Talpaz
Oct 10, 2003·The New England Journal of Medicine·John M Goldman, Junia V Melo
Dec 4, 2003·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Ellen Weisberg, James D Griffin
Feb 26, 2004·Blood·Bruno Calabretta, Danilo Perrotti
Jul 9, 2004·International Journal of Hematology·Chikashi Yoshida, Junia V Melo
Jul 24, 2004·Hematology/oncology Clinics of North America·Junia V Melo, Michael W N Deininger
Jul 24, 2004·Hematology/oncology Clinics of North America·Francis J GilesSusan M O'Brien
Aug 13, 2004·The New England Journal of Medicine·Catriona H M JamiesonIrving L Weissman
Aug 22, 2009·Medical Oncology·Janice P DutcherPeter H Wiernik

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Citations

Aug 18, 2010·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Qiuling WuMei Hong
Nov 20, 2012·Journal of Lipid Research·Tara Ann BurnsChiara Luberto
Dec 27, 2013·Journal of Clinical and Experimental Hematopathology : JCEH·Hiroko TsunemineTakayuki Takahashi
Jul 14, 2016·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Kamal Kant SahuSubhash Chandar Varma
Nov 4, 2009·Leukemia & Lymphoma·Susannah CooperMichael R Savona
May 3, 2008·Seminars in Oncology·Francis J GilesJorge Cortes
Oct 27, 2015·Clinical Lymphoma, Myeloma & Leukemia·Fernando Pérez-JacoboXavier López-Karpovitch
May 9, 2014·Current Opinion in Pulmonary Medicine·Saadia A FaizCarlos A Jimenez
Jan 14, 2017·Oncotarget·Kaushiki MukherjeeDan A Liebermann

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