Blastic plasmacytoid dendritic cell neoplasm of the breast: A case report and review of the literature.

Medicine
Hyo-Jae LeeHyo Soon Lim

Abstract

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an uncommon and aggressive hematologic malignancy that arises from plasmacytoid dendritic cells. BPDCN typically presents with skin lesions with or without involvement of lymph nodes, peripheral blood, or bone marrow. However, breast involvement of BPDCN is rare and there has been no report describing the radiologic features of BPDCN within breast parenchyma. We report a case of a 47-year-old woman who presented with an incidentally detected hypermetabolic breast lesion on PET/CT with concurrent right cheek plaque. Skin biopsy was performed for the right cheek plaque. Mammography and breast ultrasonography were performed to evaluate the breast lesion. The lesion was depicted as a 2.5 cm sized focal asymmetry on mammogram and an irregular heterogeneous echoic mass within the mammary zone of the right upper outer breast. Core needle biopsy was performed for the breast lesion. Histologic diagnosis of the two lesions was BPDCN. The patient was treated with induction and consolidation chemotherapy and received allogenic peripheral blood stem cell transplantation. The patient remains in complete remission state without relapse at 34 months since initial diagnosis. This is the fi...Continue Reading

References

Sep 18, 2003·Bone Marrow Transplantation·P ReimerM Wilhelm
Mar 30, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·D BorchielliniJ P Lacour
Oct 25, 2013·Journal of breast cancer·Euddeum ShimGil Soo Son
Aug 8, 2014·Insights Into Imaging·K N GlazebrookR T Fazzio
Oct 10, 2014·International Journal of Surgical Pathology·Ko-Chin ChenJia-Hung Liou
Oct 14, 2014·Cancer Control : Journal of the Moffitt Cancer Center·Wasif RiazLubomir Sokol
Jun 7, 2016·British Journal of Haematology·Livio PaganoAlessandro Pulsoni

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