Blastic Transformation of a Mantle Cell Lymphoma Presenting as an Enlarging Unilateral Orbital Mass

Ocular Oncology and Pathology
Matthew A De NiearLouise A Mawn

Abstract

Mantle cell lymphoma (MCL) is an uncommon form of non-Hodgkin lymphoma predominantly affecting male individuals of advanced age. Approximately 1-9% of cases of lymphoma affecting the orbital and ocular adnexal regions are attributed to MCL. We describe the case of a 65-year-old man with a 24-year history of MCL with initial remission followed by multiple relapses who presented with acute-onset binocular diplopia and proptosis of the left eye. Subsequent imaging demonstrated a new left superior orbital mass. Biopsy of the mass revealed two clonally related, yet distinct cellular components demonstrating the classical mantle cell morphology and large cells that appeared to have transformed to the blastoid variant of MCL. Transformation of classical MCL to the blastoid variant of MCL is rare, with few reports in the literature. The blastoid variant of MCL tends to be aggressive and associated with a poor prognosis. The case we describe represents perhaps the first report of MCL transformation observed in the orbit.

References

Jan 31, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N S AndersenC H Geisler
Mar 21, 2002·The Lancet Oncology·I BaristaF Cabanillas
Jan 5, 2005·Ophthalmology·Audrey LooiValerie A White
Jan 27, 2007·The American Journal of Surgical Pathology·Judith A FerryNancy L Harris
Oct 27, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A FerrerE Montserrat
May 12, 2009·The British Journal of Ophthalmology·P RasmussenS Heegaard
Jun 11, 2011·Ophthalmic Plastic and Reconstructive Surgery·Daniel B RootmanJack Rootman
Nov 21, 2012·Blood·Yvette L Kasamon, Kathleen H Burns
Apr 26, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C Y CheahUNKNOWN European Mantle Cell Lymphoma Network
Jan 13, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chan Yoon CheahMichael L Wang
Mar 2, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eva HosterWolfram Klapper
May 4, 2017·Current Oncology Reports·Sílvia Beà, Virginia Amador
May 17, 2018·British Journal of Haematology·Pamela McKaySimon Rule

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.