Jun 30, 2000

Blastocyst implantation: the adhesion cascade

Seminars in Cell & Developmental Biology
S J Kimber, C Spanswick

Abstract

This review covers the sequence of cell adhesion events occurring during implantation of the mammalian embryo, concentrating on data from mouse and human. The analogy is explored between initial attachment of trophoblast to the uterine lining epithelium and that of neutrophils to the endothelial lining of blood vessels at sites of inflammation. The possible role of various carbohydrate ligands in initial attachment of the blastocyst is reviewed. The evidence for subsequent stabilization of cell adhesion via integrins or the trophinin-tastin complex is discussed.

Mentioned in this Paper

TRO gene
Syncytiotrophoblasts
TROAP
Uterus
Blood Vessel
Neutrophils as Percentage of Blood Leukocytes (Lab Test)
Epithelium
Blastocyst Implantation, Natural
TRO
Mesothelium

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