PMID: 8463612Mar 1, 1993Paper

Blastocystis hominis in inflammatory bowel disease

Journal of Clinical Gastroenterology
J NaglerR Soave

Abstract

We retrospectively examined the hospital course of 12 patients with exacerbated inflammatory bowel disease (IBD), who also had stool specimens positive for Blastocystis hominis to determine the effect of B. hominis on their disease. Bloody bowel movements were common with ulcerative colitis patients and watery diarrhea with Crohn's disease; other findings included abdominal pain, fever, nausea, and vomiting. All patients responded favorably to medical therapy. Three responded to treatment with corticosteroids alone, and one patient improved with bowel rest without medications. Five patients failed to improve on metronidazole; four of them responded to a subsequent course of corticosteroids, whereas the fifth patient became asymptomatic after erythromycin treatment for concomitant Campylobacter jejuni. Finally, three patients responded to treatment with metronidazole alone, which is known to eradicate B. hominis but may also have a beneficial effect on IBD. In no case did corticosteroid treatment worsen the condition. Our findings indicate that B. hominis is not a significant pathogen in IBD and treatment must be directed toward the underlying illness.

Citations

Nov 14, 1997·Journal of Pediatric Gastroenterology and Nutrition·S BridgerS R Cairns
Sep 12, 2012·BMC Gastroenterology·Ayhan Hilmi CekinBasak Oguz Yolcular
Nov 30, 2004·Veterinary Parasitology·Kevin S W Tan
Feb 15, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·N G RossenT van Gool
Sep 17, 2016·Asian Pacific Journal of Tropical Medicine·Adil CoskunSema Ertug
Oct 13, 2009·Memórias do Instituto Oswaldo Cruz·Funda Dogruman-AlKenneth Boorom
Aug 27, 2009·Nature Reviews. Gastroenterology & Hepatology·Siew C Ng, Brian Gazzard
Nov 10, 2020·Parasitology International·Oľga Danišová, Alexandra Valenčáková
Oct 5, 2021·GE Portuguese Journal of Gastroenterology·Miguel Mascarenhas SaraivaGuilherme Macedo

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