Blastogenic response and EBNA induction in human lymphocytes by Epstein-Barr virus only requires B cells but not macrophages

Cancer Letters
P Gergely, I Ernberg

Abstract

The postulated role of macrophages in the primary infection of human lymphocytes by Epstein-Barr virus (EBV) was examined. Macrophage removal had no effect on the blastogenic response but slightly reduced the percentage of EBNA-positive cells induced by the B 95-8 virus strain. Both the rate of DNA synthesis and the appearance of EBNA-positive cells could rather be related to the number of B cells in the infected populations. Macrophages are thus not required for the initiation of EBV-induced lymphocyte transformation.

References

Feb 15, 1978·International Journal of Cancer. Journal International Du Cancer·L Einhorn, I Ernberg

Citations

Jan 15, 1975·International Journal of Cancer. Journal International Du Cancer·U Schneider, H zur Hausen
May 1, 1973·International Journal of Cancer. Journal International Du Cancer·B M Reedman, G Klein
Jan 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·G Miller, M Lipman
Jul 15, 1974·International Journal of Cancer. Journal International Du Cancer·J H PopeD J Moss
Jan 1, 1972·Cellular Immunology·R E ClickB J Alter

Related Concepts

Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Lymphoid Cells
Transcription Initiation
Herpesviridae Infections
Primary Infection NOS
Lymphocyte Activation
B-Lymphocytes
Epstein-Barr Virus Nuclear Antigens
Epstein-Barr Virus
Macrophage

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