Blastogenic response and EBNA induction in human lymphocytes by Epstein-Barr virus only requires B cells but not macrophages

Cancer Letters
P Gergely, I Ernberg


The postulated role of macrophages in the primary infection of human lymphocytes by Epstein-Barr virus (EBV) was examined. Macrophage removal had no effect on the blastogenic response but slightly reduced the percentage of EBNA-positive cells induced by the B 95-8 virus strain. Both the rate of DNA synthesis and the appearance of EBNA-positive cells could rather be related to the number of B cells in the infected populations. Macrophages are thus not required for the initiation of EBV-induced lymphocyte transformation.


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Jan 15, 1975·International Journal of Cancer. Journal International Du Cancer·U Schneider, H zur Hausen
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