Blasts from the past: new lessons in stem cell biology from chronic myelogenous leukemia

Cancer Cell
Brian J Huntly, D Gary Gilliland

Abstract

Cancer can be viewed as a hierarchical system that is dependent on a small population of "cancer stem cells" with unlimited self-renewal potential for continued growth and propagation of tumors. The identity and nature of these cells remains enigmatic, but an improved understanding of their biology may allow for selective therapeutic targeting. A recent report by sheds new light on leukemia stem cells by identifying the cells with in vitro self-renewing properties in various phases of chronic myelogenous leukemia, and linking the self-renewal properties of this population to activation of beta-catenin, a major effector of the canonical Wnt signaling pathway.

References

Apr 30, 2003·Nature·Tannishtha ReyaIrving L Weissman

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Citations

Jan 7, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Dov Zipori
Apr 2, 2005·Nature Reviews. Cancer·Brian J P Huntly, D Gary Gilliland
May 25, 2007·Nature Reviews. Cancer·Junia V Melo, David J Barnes
Jan 11, 2012·The Journal of Clinical Investigation·Christian SchürchAdrian F Ochsenbein
Mar 29, 2008·Cell Stem Cell·Aniruddha J Deshpande, Christian Buske
Feb 7, 2014·Current Hematologic Malignancy Reports·Andreas Burchert
Nov 6, 2007·Biochimica Et Biophysica Acta·Zainab JaganiRoya Khosravi-Far
Aug 1, 2012·The FEBS Journal·Maria V Verga FalzacappaPier G Pelicci
Oct 16, 2015·Cellular Oncology (Dordrecht)·Jessika BertacchiniNajmaldin Saki
Jun 20, 2006·Seminars in Cancer Biology·Sabina Signoretti, Massimo Loda
Dec 21, 2004·Cancer Cell·Catriona H M JamiesonEmmanuelle Passegué
Mar 29, 2008·Cell Stem Cell·Zuzana Tothova, D Gary Gilliland
Dec 13, 2005·Cancer Cell·Marc DamelinTimothy H Bestor
Mar 18, 2010·Blood·Jan E CaretteThijn R Brummelkamp
Jun 21, 2008·Acta Haematologica·Priya Koppikar, Ross L Levine

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