Bleeding and Thrombotic Events in Patients Undergoing Mechanical Circulatory Support: A Review of Literature

The Thoracic and Cardiovascular Surgeon
Mate PetricevicBojan Biocina

Abstract

Bleeding and thrombotic events are among the most common complications detected in patients with mechanical circulatory support (MCS). Herein, we reviewed the available evidence on the prevalence, etiology, and management of bleeding and thrombotic events in patients following MCS procedures, such as implantation of both intra- and paracorporeal devices that generate either pulsatile or nonpulsatile flow. Extracorporeal life support procedures providing support to the failing heart and lungs were also reviewed. Most bleeding and thromboembolic events occur despite appropriate hemostatic and anticoagulation management based on conventional coagulation laboratory parameters. Prevalence of bleeding events in this population ranges between 5 and 81%. Wide range in prevalence of bleeding reported in literature may be explained by different devices with different anticoagulation protocols being used, as well as different definitions of bleeding outcomes. Although bleeding events are more common than thromboembolic events, the consequences of thrombotic events are often detrimental. Management of bleeding events remains challenging and measures to prevent and treat bleeding events are often followed by thromboembolic events. Therefore...Continue Reading

Citations

Sep 1, 2017·Haemophilia : the Official Journal of the World Federation of Hemophilia·Nathan D GayJason A Taylor
Oct 2, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Yana Roka-MoiiaMarvin J Slepian
Feb 5, 2021·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Do Hyung KimSung Kwang Lee
Feb 6, 2021·Clinics in Chest Medicine·Laura M PiechuraHari R Mallidi
Nov 3, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Yana Roka-MoiiaMarvin J Slepian

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