Bleeding patterns and clinical performance of the levonorgestrel-releasing intrauterine system (Mirena) up to two years

Contraception
Margarete HidalgoCarlos A Petta

Abstract

The objectives of this study were to evaluate the bleeding patterns and clinical performance during the first 2 years of use of an intrauterine system releasing 20 microg/day of levonorgestrel (LNG-IUS, Mirena). Two-hundred-fifty-six women accepted use of Mirena from April 1998 through September 1998. The gross cumulative discontinuation rate due to pregnancy and expulsion were significantly higher in women who used the device because of heavy bleeding. There was one pregnancy at the 15th month of use after an inadvertent expulsion of the device. The continuation rate was 66.2 at the end of the second year. Forty-four percent of women reported amenorrhea at the 6th month of use. This rate maintained stability at 50% after 12 and 24 months of use. Spotting was present in 25% of the users at 6 months, decreasing to 8% and 11% at 18 and 24 months, respectively. Oligomenorrhea was described by one-quarter of women and was similar at each observation period. Removals due to menstrual bleeding problems were concentrated in the first 6 months of use and mostly due to amenorrhea or menorrhagia. In conclusion, LNG-IUS showed a high contraceptive efficacy and a good continuation rate up to 2 years. In addition, a reduction of blood loss ...Continue Reading

References

Jul 1, 1990·Contraception·I BarbosaE D Johansson
Apr 1, 1993·Annals of Medicine·A FaúndesJ Díaz
Mar 15, 2000·Contraception·D HubacherD Taylor
Mar 31, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·T BackmanM Koskenvuo
Feb 24, 2001·BJOG : an International Journal of Obstetrics and Gynaecology·A StewartW Phillips
Jun 27, 2001·Human Reproduction·UNKNOWN ESHRE Capri Workshop Group

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Citations

Aug 11, 2004·Fertility and Sterility·UNKNOWN Practice Committee, American Society for Reproductive Medicine
Sep 15, 2004·Fertility and Sterility·UNKNOWN Practice Committee of the American Society for Reproductive Medicine
Oct 18, 2002·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R Varma, L Mascarenhas
Feb 11, 2005·The Nurse Practitioner·Mandy J Johnson, Katherine W Morgan
Aug 2, 2003·Current Opinion in Pediatrics·Andrea Pettinato, S Jean Emans
Aug 21, 2013·The Nurse Practitioner·Joyce Cappiello, Julie Bosak
Aug 27, 2005·Obstetrical & Gynecological Survey·Jeffrey T Jensen
Sep 22, 2007·Current Opinion in Obstetrics & Gynecology·Rachel J MillerThomas H Inge
Jul 12, 2012·Current Opinion in Obstetrics & Gynecology·Colleen McNicholas, Jeffrey F Peipert
Nov 6, 2007·Clinical Obstetrics and Gynecology·Camaryn ChrismanVanessa K Dalton
Jun 26, 2007·Archives of Disease in Childhood·Assunta Albanese, Neil W Hopper
Jun 22, 2005·Treatments in Endocrinology·Lee P Shulman
Jun 15, 2011·Drugs·Amy StoddardJeffrey F Peipert
Dec 25, 2012·Journal of Immigrant and Minority Health·DeShawn TaylorPenina Segall-Gutierrez
Aug 12, 2014·Current Opinion in Obstetrics & Gynecology·Anna Lea Altshuler, Paula J Adams Hillard
Sep 1, 2005·Women's Health·Regine Sitruk-Ware, Pirjo Inki
Apr 28, 2009·Women's Health·Martha HickeySweta Agarwal
Oct 22, 2011·Obstetrics and Gynecology·Kari P BraatenAlisa B Goldberg
Oct 10, 2013·Obstetrics and Gynecology·Micaela Oʼneil-CallahanGina Secura
Dec 14, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Tiina Backman
Nov 20, 2012·Journal of Pediatric and Adolescent Gynecology·Kelly L Kantartzis, Gina S Sucato
Apr 3, 2013·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Paula J Adams Hillard
Apr 3, 2013·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Lisa L Bayer, Paula J Adams Hillard
Apr 3, 2013·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Jennefer A RussoMelanie A Gold
Sep 11, 2012·Current Problems in Pediatric and Adolescent Health Care·Lauren B HartmanLoris Y Hwang
Feb 25, 2011·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Malcolm G MunroUNKNOWN FIGO Working Group on Menstrual Disorders
Dec 19, 2015·The American Journal of Cardiology·Quyen VuSarah Prager
Dec 3, 2015·Women's Health·Natalie S Whaley, Anne E Burke
Jun 23, 2009·Journal of Pediatric and Adolescent Gynecology·I SavasiM P Ornstein
Jun 16, 2009·Maturitas·Sarah M R Hardman, Ailsa E Gebbie
Oct 3, 2015·Pediatric Annals·Sarah E Strandjord, Ellen S Rome
Feb 7, 2009·Best Practice & Research. Clinical Obstetrics & Gynaecology·Zara Haider, Rachel D'Souza
Jul 14, 2006·Mayo Clinic Proceedings·Paru S DavidJulia A Files
Nov 26, 2008·Fertility and Sterility·UNKNOWN Practice Committee of American Society for Reproductive Medicine
May 20, 2008·Obstetrics and Gynecology Clinics of North America·Kristen A Plastino, Patricia J Sulak
Jun 25, 2008·Annals of the New York Academy of Sciences·Elisabeth H Quint
Mar 19, 2013·The Journal of Obstetrics and Gynaecology Research·David KuzelMichal Mara

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