PMID: 11910662Mar 26, 2002Paper

Bleeding patterns and endometrial histology during administration of low-dose estradiol sequentially combined with dydrogesterone

Climacteric : the Journal of the International Menopause Society
P H van de WeijerP Kenemans

Abstract

To determine bleeding patterns and endometrial response in postmenopausal women taking low-dose (1 mg) estradiol in a sequential combined formulation with 5 or 10 mg dydrogesterone. A total of 151 postmenopausal women were allocated randomly to 5 or 10 mg dydrogesterone during cycle days 15-28 in a sequential oral formulation with 1 mg estradiol continuously during 13 cycles of 28 days. Occurrence of vaginal bleeding was recorded daily and analyzed in accordance with World Health Organization (WHO) standards. Endometrial biopsies, obtained at baseline and cycle days 25-27 of the final treatment cycle, were interpreted independently by two pathologists. The study was completed by 131 women (87%). The percentage of women with bleeding (mean +/- SD) was 57.2 +/- 3.6% in the 1/5-mg group and 65.8 +/- 4.2% in the 1/10-mg group (p < 0.001); cross-sectional analysis showed that, in every cycle, there were more women with bleeding in the 1/10-than in the 1/5-mg group (p < 0.001). With regard to the day of onset of bleeding, the mean difference between groups was 1.4 +/- 1.1 days (p < 0.001). There was no difference in duration of bleed (5 days), or intensity or incidence of intermittent bleeding (3-14% per cycle). Both regimens resulte...Continue Reading

References

Dec 15, 1992·Annals of Internal Medicine·D GradyS R Cummings
Aug 1, 1995·Obstetrics and Gynecology·L UdoffE Y Adashi
Feb 1, 1995·Obstetrics and Gynecology·D GradyD Petitti
Sep 1, 1996·Human Reproduction·M HickeyP A Rogers
Jan 9, 1999·Maturitas·P H van de WeijerP Kenemans

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Citations

Dec 26, 2007·Pathology Oncology Research : POR·Zoltan MagyarZoltan Papp
Jun 18, 2002·Maturitas·Toon Van Gorp, Patrick Neven
Jul 11, 2014·American Journal of Epidemiology·Agnès FournierNathalie Chabbert-Buffet
Dec 6, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Harald Seeger, Alfred O Mueck
Oct 20, 2009·Maturitas·Alfred O MueckKai-J Bühling
Aug 1, 2018·Hormone Molecular Biology and Clinical Investigation·Alfred O Mueck, Thomas Römer
Aug 17, 2012·The Cochrane Database of Systematic Reviews·Susan FurnessAnne Lethaby

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