Bleeding phenotype of patients with moderate haemophilia A and B assessed by thromboelastometry and thrombin generation.

Haemophilia : the Official Journal of the World Federation of Hemophilia
Ragnhild J MåseidePål A Holme

Abstract

Predicting the bleeding phenotype is crucial for the management of patients with moderate haemophilia. Global coagulation assays evaluate haemostasis more comprehensively than conventional methods. To explore global coagulation assays and the bleeding phenotype of patients with moderate haemophilia A (MHA) and B (MHB). The MoHem study is a cross-sectional, multicentre study covering Nordic patients with MHA and MHB. Thromboelastometry in whole blood and thrombin generation (TG) in platelet-poor plasma (1, 2.5 and 5 pM tissue factor (TF)) were compared with joint health (Haemophilia Joint Health Score (HJHS)) and treatment modality. We report on 61 patients from Oslo and Helsinki: 24 MHA and 37 MHB. By TG (2.5 pM TF), patients who had been without replacement therapy during the previous 12 months depicted higher endogenous thrombin potential (P = .03). In contrast, those who had low ETP (< median) captured higher HJHS (P = .02). Patients who had undergone orthopaedic surgery generated least thrombin (P = .02). By thromboelastometry, those without the need of factor consumption had short clotting times, and quick times to maximum velocity (< median values) (P = .03). Factor VIII/factor IX activity (FVIII/FIX:C) did not align with...Continue Reading

References

Jun 19, 2002·Blood·Kathleen E BrummelKenneth G Mann
Jul 11, 2003·Pathophysiology of Haemostasis and Thrombosis·H Coenraad HemkerSuzette Béguin
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·B SørensenJ Ingerslev
Nov 20, 2004·Journal of Thrombosis and Haemostasis : JTH·R Luddington, T Baglin
Mar 1, 2005·Thrombosis and Haemostasis·Yesim DargaudClaude Negrier
Jul 14, 2005·Haemophilia : the Official Journal of the World Federation of Hemophilia·C P Beltrán-MirandaM A Laffan
Aug 22, 2006·Haemophilia : the Official Journal of the World Federation of Hemophilia·P HilliardB M Feldman
Aug 4, 2007·British Journal of Haematology·S J LewisP W Collins
May 22, 2008·British Journal of Haematology·Meera ChitlurJeanne M Lusher
Nov 18, 2008·Thrombosis Research·Joost J van VeenMike Makris
Jan 28, 2010·Journal of Thrombosis and Haemostasis : JTH·E SantagostinoP M Mannucci
Feb 13, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·R GilmoreP V Jenkins
Jul 16, 2010·Journal of Thrombosis and Haemostasis : JTH·F RodeghieroUNKNOWN ISTH/SSC joint VWF and Perinatal/Pediatric Hemostasis Subcommittees Working Group
May 7, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·I E M Den UijlK Fischer
Jun 21, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·U Wartiovaara-KauttoR Lassila
Jul 6, 2012·Blood Reviews·Raed Al DieriH Coenraad Hemker
Jul 3, 2013·Haematologica·Annette E BowyerMichael Makris
Nov 23, 2013·Journal of Thrombosis and Haemostasis : JTH·M ChitlurUNKNOWN Factor VIII, Factor IX, and Rare Coagulation Disorders Subcommittee of the Scientific and Standardisation Committee of the I
Feb 13, 2014·Haemophilia : the Official Journal of the World Federation of Hemophilia·M TrossaertY Dargaud
Jul 26, 2014·Journal of Thrombosis and Haemostasis : JTH·V S BlanchetteA Srivastava
Dec 15, 2015·Journal of Thrombosis and Haemostasis : JTH·F PeyvandiK D Friedman
Apr 26, 2017·Haemophilia : the Official Journal of the World Federation of Hemophilia·K KihlbergJ Astermark
Jun 29, 2017·Journal of Thrombosis and Haemostasis : JTH·Y DargaudUNKNOWN Subcommittee on Factor VIII, Factor IX, and Rare Coagulation Disorders
Feb 29, 2020·Research and Practice in Thrombosis and Haemostasis·Saman AghighiPratima Chowdary
Aug 4, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Alok SrivastavaUNKNOWN WFH Guidelines for the Management of Hemophilia panelists and co-authors
Oct 7, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Ragnhild J MåseidePål A Holme

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Haemophilia : the Official Journal of the World Federation of Hemophilia
Ragnhild J MåseidePål A Holme
Haemophilia : the Official Journal of the World Federation of Hemophilia
A OlssonF Baghaei
Haemophilia : the Official Journal of the World Federation of Hemophilia
N ClausenPedNet and Research of Determinants of Inhibitor development (RODIN) Study Group
© 2021 Meta ULC. All rights reserved